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P1269

Sigma-Aldrich

Phorbol 12,13-dibutyrate

≥98% (TLC), powder, PKC activator

Sinônimo(s):

PDBu

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About This Item

Fórmula empírica (Notação de Hill):
C28H40O8
Número CAS:
37558-16-0
Peso molecular:
504.61
Beilstein:
6551234
Número MDL:
MFCD00036783
Código UNSPSC:
12352211
ID de substância PubChem:
24898178
NACRES:
NA.77

product name

Phorbol 12,13-dibutyrate, ≥98% (TLC), powder

Nível de qualidade

100

Ensaio

≥98% (TLC)

forma

powder

cor

clear light yellow, film

solubilidade

H2O: 30 μM
DMSO: soluble
acetone: soluble
ethanol: soluble

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@@]3(O)[C@H]2C=C(C)C3=O)[C@@H]4C(C)(C)[C@]14OC(=O)CCC

InChI

1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1

chave InChI

BQJRUJTZSGYBEZ-YVQNUNKESA-N

Informações sobre genes

mouse ... Prkcd(18753)

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Aplicação

Phorbol 12,13-dibutyrate has been used as a protein kinase C (PKC) activator to study its effects on human organic anion transporter 4 (hOAT4) activity. It has also been used as a PKC activator to analyze its effects on galectin-3 expression and matrix production in HL-1 cells.

Ações bioquímicas/fisiológicas

Phorbol 12,13-dibutyrate (PDBu) is a potent activator of protein kinase C (PKC). It is more hydrophilic than phorbol 12-myristate 13-acetate (PMA), which facilitates washing PDBu out of cells in tissue culture. PDBu activates endothelial nitric oxide synthase expression in primary human umbilical vein endothelial cells, which in turn correlates with PKC α and ε expression.

Características e benefícios

Less hydrophobic then PMA, making it easier to wash out of cells in tissue culture.

Atenção

Photosensitive

Reconstituição

Stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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The Journal of biological chemistry, 278(20), 18448-18454 (2003-03-07)
Diacylglycerol kinase (DGK) and protein kinase C (PKC) are two distinct enzyme families associated with diacylglycerol. Both enzymes have cysteine-rich C1 domains (C1A, C1B, and C1C) in the regulatory region. Although most PKC C1 domains strongly bind phorbol esters, there
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Conventional and novel protein kinase C (PKC) isozymes contain two cysteine-rich C1 domains (C1A and C1B), both of which are candidate phorbol-12, 13-dibutyrate (PDBu)-binding sites. We synthesized C1 peptides of 50-70 residues corresponding to all PKC isozyme C1 domains using
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