MAK088
DPP4 Activity Assay Kit
sufficient for 100 fluorometric tests
Sinônimo(s):
CD26 Activity Assay Kit, Deaminase Complexing Protein 2 Activity Assay Kit, Dipeptidyl Peptidase-4 Activity Assay Kit
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About This Item
Produtos recomendados
uso
sufficient for 100 fluorometric tests
método de detecção
fluorometric
temperatura de armazenamento
−20°C
Informações sobre genes
human ... DPP4(1803)
mouse ... DPP4(13482)
rat ... DPP4(25253)
Descrição geral
Dipeptidyl peptidase-4 (DPP4), also known as CD26 and adenosine deaminase complexing protein 2, is a serine exopeptidase that cleaves X-Proline and X-Alanine residues from the N-termini of polypeptides. DPP4 is a transmembrane glycoprotein whose activity regulates the bioactivity of multiple peptides such as growth factors, chemokines, and neuropeptides. DPP4 plays a major role in glucose metabolism via the regulation of glucagon-like peptide-1 and inhibitors of DPP4 are commonly used for the treatment of type 2 diabetes. DPP4 also plays an important role in immune regulation and may play a role in tumor suppression. Deletion of the DPP4 gene affects carbohydrate metabolism which in turn leads to mental retardation and hypotonia. Abnormal expression of the protein is observed during liver regeneration, cirrhosis and liver tumorigenesis.
Aplicação
DPP4 Activity Assay Kit has been used to determine the activity of dipeptidyl peptidase-4 (DPP4) in homogenates.
Características e benefícios
Compatible with high-throughput handling systems.
Adequação
Suitable for the measurement of dipeptidyl peptidase-4 (DPP4) in a variety of samples including tissue, cells and serum
Princípio
The DPP4 Activity Assay kit provides a simple and direct procedure for measuring DPP4 activity in a variety of samples. In this assay, DPP4 cleaves a non-fluorescent substrate, H-Gly-Pro-AMC, to release a fluorescent product, 7-Amino-4-Methyl Coumarin (AMC) (λex = 360/λem = 460 nm). One unit of DPP4 is the amount of enzyme that will hydrolyze the DPP4 substrate to yield 1.0 μmole of AMC per minute at 37 °C.
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
188.6 °F - closed cup
Ponto de fulgor (°C)
87 °C - closed cup
Certificados de análise (COA)
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Abbott C A, et al.
Cellular peptidases in immune functions and diseases, 161-169 (1997)
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Platelet-derived growth factor-B (PDGF-B) is a main factor to promote adipose tissue angiogenesis, which is responsible for the tissue expansion in obesity. In this process, PDGF-B induces the dissociation of pericytes from blood vessels; however, its regulatory mechanism remains unclear.
Active phytochemicals of Pueraria tuberosa for DPP-IV inhibition: in silico and experimental approach.
Srivastava S, et al.
Journal of diabetes and metabolic disorders, 16(1), 46-46 (2017)
Dipeptidyl peptidase-4 is highly expressed in bronchial epithelial cells of untreated asthma and it increases cell proliferation along with fibronectin production in airway constitutive cells.
Shiobara T, et al.
Respiratory Research, 17(1), 28-28 (2016)
Heidi Noels et al.
Scientific reports, 8(1), 11820-11820 (2018-08-09)
Cardiac surgery with cardiopulmonary bypass (CPB) triggers myocardial ischemia/reperfusion injury contributing to organ dysfunction. Preclinical studies revealed that dipeptidyl peptidase (DPP4) inhibition is protective during myocardial infarction. Here, we assessed for the first time the relation of peri-operative DPP4-activity in
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