M4145

Minoxidil

≥99% (TLC), powder, androgenetic alopecia drug

• Sinônimo(s): 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
• Fórmula empírica (Notação de Hill): C₉H₁₅N₅O
• Número CAS: 38304-91-5
• Peso molecular: 209.25
• Número CE: 253-874-2
• Número MDL: MFCD00063409
• Código UNSPSC: 12352200
• ID de substância PubChem: 24277853
• NACRES: NA.77

Propriedades

• product name: Minoxidil, ≥99% (TLC)
• Ensaio: ≥99% (TLC)
• pf: 272-274 °C (dec.) (lit.)
• originador: Johnson & Johnson
• cadeia de caracteres SMILES: NC1=CC(=NC(=N)N1O)N2CCCCC2
• InChI: 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
• chave InChI: ZIMGGGWCDYVHOY-UHFFFAOYSA-N
• Informações sobre genes: human ... KCNJ1(3758)

Descrição

Aplicação

Minoxidil has been used as test drug:

• in dermal papilla spheroid model, to study the effect of hair regeneration
• administered orally to experimental rats, in the approach to identify biomarkers of drug induced vascular injury
• administered via oral gavage to nonhuman primate model in order to study its effect on tilt responses

Ações bioquímicas/fisiológicas

Minoxidil is originally used to treat hypertension, which also induces hypertrichosis. It is considered as a potent drug for treating androgenetic alopecia.

Activates ATP-activated K⁺ channels; vasodilator; slow or stop hair loss and promote hair regrowth.

Características e benefícios

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302,H315,H319,H335
• Declarações de precaução: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves