M1196

Anti-Mucolipin-2 (C-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Sinônimo(s): Anti-MCOLN2, Anti-MLN2, Anti-TRPML2
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 200
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: antigen ~60 kDa
• reatividade de espécies: human
• embalagem: antibody small pack of 25 μL
• validação aprimorada: recombinant expression; Learn more about Antibody Enhanced Validation
• concentração: ~1 mg/mL
• técnica(s): western blot: 0.3-0.6 μg/mL using HEK-293T cells expressing human mucolipin-2
• nº de adesão UniProt: Q8IZK6
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... MCOLN2(255231)

Descrição

Descrição geral

Mucolipin-2 (MLN2) is a member of transient receptor potential (TRP) protein superfamily. It consists of gated, tetrameric cation channels. MLN2 has a conserved structure of six transmembrane helices with differing cytoplasmic oriented N- and C-terminal domains. It is localized to late endosomes and lysosomes..

Especificidade

Additional bands may be observed at ~120 kDa and ~35 kDa due to aggregation and degradation, respectively.

Imunogênio

synthetic peptide corresponding to amino acids 534-549 of human mucolipin-2. This sequence has low homology with rat (73% identity) and mouse (66% homology) mucolipin-2.

Aplicação

Anti-Mucolipin-2 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

Ações bioquímicas/fisiológicas

Mucolipin-2 (MLN2) plays an important role in lysosome maturation, lysosome fission, late endosome-lysosome fusion, autophagosome-lysosome fusion, lysosome expulsion and iron release. It stimulates autophagy proliferation via transcription factor EB (TFEB) activation. MLN2 is involved in B‐lymphocyte development.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)