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M0267

Sigma-Aldrich

(±)-Methadone hydrochloride

powder, ≥98%

Sinônimo(s):

6-Dimethylamino-4,4-diphenylheptan-3-one hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C21H27NO · HCl
Número CAS:
1095-90-5
Peso molecular:
345.91
Número CE:
214-140-7
Número MDL:
MFCD00058014
Código UNSPSC:
12352200
ID de substância PubChem:
24896546
NACRES:
NA.77

Ensaio

≥98%

Formulário

powder

controle de medicamentos

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

cor

white to off-white

solubilidade

H2O: 50 mg/mL, clear, colorless to yellow

originador

Novartis

cadeia de caracteres SMILES

Cl.CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c2ccccc2

InChI

1S/C21H27NO.ClH/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6-15,17H,5,16H2,1-4H3;1H

chave InChI

FJQXCDYVZAHXNS-UHFFFAOYSA-N

Informações sobre genes

human ... OPRM1(4988)

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Ações bioquímicas/fisiológicas

μ opioid receptor agonist that desensitizes both the μ opioid receptor and the δ opioid receptor on chronic exposure; narcotic analgesic, characterized by a gradual onset of action and prolonged, milder withdrawal; may also block L-type calcium channels independently of its effects on opioid receptors.

Características e benefícios

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H300,H336

Classificações de perigo

Acute Tox. 2 Oral - STOT SE 3

Órgãos-alvo

Central nervous system

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
SLCL4525
SLCJ0320
SLBZ0874
SLBW1847
SLBV8090

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Visite a Biblioteca de Documentos

A D Blake et al.
The Journal of biological chemistry, 272(2), 782-790 (1997-01-10)
Mu opioid receptors mediate the analgesia induced by morphine. Prolonged use of morphine causes tolerance development and dependence. To investigate the molecular basis of tolerance and dependence, the cloned mouse mu opioid receptor with an amino-terminal epitope tag was stably
Y Yu et al.
The Journal of biological chemistry, 272(46), 28869-28874 (1997-11-20)
Mu opioid receptors are subject to phosphorylation and desensitization through actions of at least two distinct biochemical pathways: agonist-dependent mu receptor phosphorylation and desensitization induced by a biochemically distinct second pathway dependent on protein kinase C activation (1). To better
Olivier René et al.
Nucleic acids research, 39(5), 1855-1867 (2010-11-10)
The late stages of 30S and 50S ribosomal subunits biogenesis have been studied in a wild-type (wt) strain of Escherichia coli (MC4100) subjected to a severe heat stress (45-46°C). The 32S and 45S ribosomal particles (precursors to 50S subunits) and
Kathleen M Carroll et al.
The American journal of psychiatry, 171(4), 436-444 (2014-03-01)
A previous pilot trial evaluating computer-based training for cognitive-behavioral therapy (CBT4CBT) in 77 heterogeneous substance users (alcohol, marijuana, cocaine, and opioids) demonstrated preliminary support for its efficacy in the context of a community-based outpatient clinic. The authors conducted a more
David F Katz et al.
The American journal of cardiology, 112(7), 1013-1018 (2013-07-04)
Methadone is highly effective for opioid dependency, but it is associated with Torsade de pointes. Although electrocardiography (ECG) has been proposed, its utility is uncertain, because an ECG-based intervention has not been described. An ECG-based cardiac safety program in methadone
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