K2015

K-252a

Ready Made Solution, from Nonomuraea longicatena, >98%

• Sinônimo(s): SF 2370
• Fórmula empírica (Notação de Hill): C₂₇H₂₁N₃O₅
• Número CAS: 99533-80-9
• Peso molecular: 467.47
• Número CE: 200-664-3
• Número MDL: MFCD00161522
• Código UNSPSC: 12352200
• ID de substância PubChem: 329817131
• NACRES: NA.77

Propriedades

• fonte biológica: Nonomuraea longicatena
• Nível de qualidade: 200
• Ensaio: >98%
• Formulário: solution
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
• chave InChI: KOZFSFOOLUUIGY-SOLYNIJKSA-N
• Informações sobre genes: human ... NTRK1(4914) ; rat ... Prkca(24680)

Descrição

Ações bioquímicas/fisiológicas

K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor. At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures. K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c. K-252a improves psoriasis in a SCID mouse-human skin model and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.

Características e benefícios

This compound is featured on the Met and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

forma física

Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): 188.6 °F - closed cup
• Ponto de fulgor (°C): 87 °C - closed cup
• Equipamento de proteção individual: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)