About This Item
Fórmula empírica (Notação de Hill):
C20H30O2
Número CAS:
Peso molecular:
302.45
Número MDL:
Código UNSPSC:
12352106
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
Nível de qualidade
Ensaio
≥98% (GC)
Formulário
powder
cor
white
solubilidade
DMSO: 25 mg/mL
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
[H][C@]12CC[C@@](C)(CC1=CC[C@@]3([H])[C@@](C)(CCC[C@]23C)C(O)=O)C=C
InChI
1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,7,15-16H,1,6,8-13H2,2-4H3,(H,21,22)/t15-,16+,18-,19+,20+/m0/s1
chave InChI
MXYATHGRPJZBNA-KRFUXDQASA-N
Descrição geral
Isopimaric acid, a resin acid produced by conifer trees, is a tricyclic diterpene compound. High levels of isopimaric acid in the hepatocytes of the rainbow trout may impair calcium signalling machinery. Isopimaric acid is a potential big potassium (BK) channel opener.
Ações bioquímicas/fisiológicas
Potent opener of large conductance calcium activated K+ (BK) channels.
Características e benefícios
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Aquatic Acute 1
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Neil C Henney et al.
American journal of physiology. Cell physiology, 297(6), C1397-C1408 (2009-09-25)
The pharmacology of the large-conductance K(+) (BK) channel in human osteoblasts is not well defined, and its role in bone is speculative. Here we assess BK channel properties in MG63 cells and primary human osteoblasts and determine whether pharmacological modulation
Eileen Smith et al.
Phytotherapy research : PTR, 19(6), 538-542 (2005-08-23)
The diterpene isopimaric acid was extracted from the immature cones of Pinus nigra (Arnold) using bioassay-guided fractionation of a crude hexane extract. Isopimaric acid was assayed against multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) were
Yuji Imaizumi et al.
Molecular pharmacology, 62(4), 836-846 (2002-09-19)
Effects of pimaric acid (PiMA) and eight closely related compounds on large-conductance K(+) (BK) channels were examined using human embryonic kidney (HEK) 293 cells, in which either the alpha subunit of BK channel (HEKBKalpha) or both alpha and beta1 (HEKBKalphabeta1)
Dawn E Hall et al.
Plant physiology, 161(2), 600-616 (2013-02-02)
Diterpene resin acids (DRAs) are major components of pine (Pinus spp.) oleoresin. They play critical roles in conifer defense against insects and pathogens and as a renewable resource for industrial bioproducts. The core structures of DRAs are formed in secondary
Isolation and characterization of isopimaric acid-degrading bacteria from a sequencing batch reactor.
Wilson AE, et al.
Applied and Environmental Microbiology, 62(9), 3146-3151 (1996)
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