Pular para o conteúdo
Merck
Todas as fotos(1)

Key Documents

I0531

Sigma-Aldrich

Interleukin-18 from rat

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Faça loginpara ver os preços organizacionais e de contrato


About This Item

Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.32

fonte biológica

rat

Nível de qualidade

recombinante

expressed in E. coli

Ensaio

>97% (SDS-PAGE)

forma

lyophilized powder

potência

10-60 ng/mL ED50

peso molecular

predicted mol wt ~18.4 kDa

embalagem

pkg of 25 μg

Impurezas

endotoxin, tested

nº de adesão UniProt

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

Informações sobre genes

rat ... Il18(29197)

Ações bioquímicas/fisiológicas

Interleukin 18, also known as interferon-γ-inducing factor (IGIF) and IL-1γ, is a proinflammatory cytokine. It is an inducer of IFN-γ and Th1 (T cell helper type 1) responses (cell differentiation, cell-mediated cytotoxicity and inflammation). IL-18 induces the migration of microvascular endothelial cells.

forma física

Lyophilized from 20 mM Tris , 500 mM NaCl, 0.5 mM EDTA, 1 mM TCEP, 0.05% (w/v) PEG8000 pH 8.0 with 5% Trehalose,and 50 μg BSA per μg IL-18

Nota de análise

The biological activity is measured by its ability to induce mouse IFN-γ production by activated mouse T cells.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Weiyi He et al.
Cytokine, 68(1), 32-39 (2014-05-03)
CD4(+) T cell polarization plays a critical role in the pathogenesis of allergy. How to modulate the skewed CD4(+) T cell polarization is less clear. The specific immunotherapy (SIT) is the only specific remedy for the treatment of allergic diseases;
M Dagenais et al.
Mucosal immunology, 9(1), 146-158 (2015-06-04)
Cellular inhibitors of apoptosis proteins (cIAPs) are critical arbiters of cell death and key mediators of inflammation and innate immunity. cIAP2 is frequently overexpressed in colorectal cancer and in regenerating crypts of ulcerative colitis patients. However, its corresponding functions in
Camille Guillerey et al.
Oncoimmunology, 4(9), e1027468-e1027468 (2015-09-26)
The Toll-like receptor 3 (TLR3) agonist poly(I:C) is a promising adjuvant for cancer vaccines due to its induction of potent antitumor responses occurring primarily through the activation of dendritic cells (DCs) and natural killer (NK) cells. However, little is known
Jochem W van der Veen et al.
Regulatory toxicology and pharmacology : RTP, 69(3), 371-379 (2014-05-13)
The currently available animal-free methods for the detection of skin sensitizing potential of chemicals seem promising. However, no single method is able to comprehensively represent the complexity of the processes involved in skin sensitization. To ensure a mechanistic basis and
Anders Elm Pedersen et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 123(7), 547-555 (2015-04-25)
TL1A is a TNF-like cytokine which has been shown to co-stimulate TH1 and TH17 responses during chronic inflammation. The expression of this novel cytokine has been investigated in inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease, but little is

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica