H0160
HIV-1 gag
≥95% (SDS-PAGE), recombinant, expressed in E. coli, Galactosidase-tagged
Sinônimo(s):
p24 HIV antigen
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About This Item
Produtos recomendados
recombinante
expressed in E. coli
Nível de qualidade
Ensaio
≥95% (SDS-PAGE)
peso molecular
39 kDa (plus 114 kDa β-Gal tag)
concentração
1 mg/mL
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
human immunodeficiency virus 1 ... gag(155030)
Descrição geral
Contains amino acid residues [77-436] of HIV-1 gag antigen.
The human immunodeficiency virus 1 (HIV−1) gag antigen is a recombinant 39 kDa protein encoded by the GAG gene of the human immunodeficiency virus (HIV) type I expressed in and isolated from Escherichia coli. It has a β−galactosidase tag (114 kDa) on the N−terminus. HIV-1 Gag exists as monomers or lower-order oligomers in the cytosol. At the plasma membrane, it forms higher-order multimers.
Aplicação
HIV-1 gag has been used in the coculture with an autologous cluster of differentiation T (CD4+ T) to study the ability of monocyte-derived dendritic cells (MDC1) to induce human immunodeficiency virus 1 (HIV−1) latency reversal (LR).
Ações bioquímicas/fisiológicas
The human immunodeficiency virus 1 (HIV−1) gag (p24) antigen reacts strongly with HIV positive serum and may be used as a positive control for evaluating antibodies to HIV. At transcription sites, HIV-1 Gag creates ribonucleoprotein complexes with unspliced viral RNA. The HIV-1 Gag protein is accountable for packaging genomic RNA (gRNA) and the assembly of immature viral particles.
Positive control for HIV antibodies.
forma física
Solution in 8 M urea, 20 mM Tris-HCl, pH 8.0, 10 mM 2-mercaptoethanol.
Código de classe de armazenamento
6.2 - Infectious substances
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
C T Wang et al.
Journal of medical virology, 59(2), 180-188 (1999-08-25)
The incorporation of human immunodeficiency virus type 1 (HIV-1) Gag-beta-galactosidase (Gag-beta-gal; GBG) fusion proteins into HIV virus-like particles in the presence of HIV Gag proteins was studied. HIV Gag-beta-gal fusion constructs were cotransfected individually into COS7 cells with or without
Samantha Sarni et al.
The Journal of biological chemistry, 295(42), 14391-14401 (2020-08-21)
The HIV-1 Gag protein is responsible for genomic RNA (gRNA) packaging and immature viral particle assembly. Although the presence of gRNA in virions is required for viral infectivity, in its absence, Gag can assemble around cellular RNAs and form particles
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