E9530
Erythropoietin from mouse
recombinant, expressed in NSO cells, ≥90% (SDS-PAGE), lyophilized powder, suitable for cell culture
Sinônimo(s):
EPO
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About This Item
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
recombinante
expressed in NSO cells
Ensaio
≥90% (SDS-PAGE)
forma
lyophilized powder
potência
1.030 ng/mL
peso molecular
~36 kDa by SDS-PAGE
predicted mol wt 18.6 kDa
embalagem
pkg of 10 μg
condição de armazenamento
avoid repeated freeze/thaw cycles
técnica(s)
cell culture | mammalian: suitable
Impurezas
endotoxin, tested
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
mouse ... Epo(13856)
Categorias relacionadas
Descrição geral
EPO (erythropoietin) gene is localized to human chromosome 7q22. This protein is predominantly produced by the cortex cells of kidney, as well as a variety of tissues including female reproductive organs. It is a glycoprotein, which has a molecular weight of 34kDa. It is produced as a 193-amino acid precursor protein, which is cleaved to produce a secreted protein of 166-amino acid.
Ações bioquímicas/fisiológicas
EPO (erythropoietin) plays an essential role in the growth and differentiation of erythrocyte progenitor cells. It is involved in the pathogenesis of myomatous erythrocytosis syndrome, which is characterized by erythrocytosis and myomatous uterus. It acts as a ligand for a homodimer of EPO-receptor (Epo-R), which is localized to the surface of immature erythroid cells. This interaction leads to inhibition of apoptosis and facilitation of cell proliferation and differentiation to mature erythrocytes.
Erythropoietin is a glycoprotein that is the principal regulator of red blood cell growth and differentiation.
forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.
Nota de análise
The biological acitivity is measured by its ability to stimulate cell proliferation using TF-1 cell line.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
Certificados de análise (COA)
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L T Vlasveld et al.
The Netherlands journal of medicine, 66(7), 283-285 (2008-07-30)
Myomatous erythrocytosis syndrome is defined by the combination of erythrocytosis, myomatous uterus and persistent restoration of normal haematological values after hysterectomy. A pathogenic role of erythropoietin is suggested by clinical and experimental data. A postmenopausal patient is described with the
Norio Suzuki
The Tohoku journal of experimental medicine, 235(3), 233-240 (2015-03-20)
Erythrocytes play an essential role in the delivery of oxygen from the lung to every organ; a decrease in erythrocytes (anemia) causes hypoxic stress and tissue damage. To maintain oxygen homeostasis in adult mammals, when the kidney senses hypoxia, it
Sheila E Francis
Methods in molecular biology (Clifton, N.J.), 330, 331-340 (2006-07-19)
The development of techniques for the in vitro differentiation of mouse embryonic stem (ES) cells has provided researchers with the tools to investigate vascular development as would occur in an early embryo. Mice lacking the vascular integrins have various defects
Luca Weltert et al.
Transfusion, 55(7), 1644-1654 (2015-02-24)
We conducted a prospective single-blind randomized study to assess whether a single 80,000 IU dose of human recombinant erythropoietin (HRE), given just 2 days before cardiac surgery, could be effective in reducing perioperative allogeneic red blood cell transfusion (aRBCt). Six-hundred
Honghao Zhang et al.
Experimental and therapeutic medicine, 10(5), 1925-1930 (2015-12-08)
Chronic kidney disease (CKD) is commonly accompanied by inflammation and anemia; however, the pathogenesis of CKD is unclear. Expression of resistin, a cysteine-rich secretory plasma protein, is correlated with the expression of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and lipoprotein-associated
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