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E4632

Sigma-Aldrich

Econazole nitrate salt

Sinônimo(s):

1-(2-[(4-Chlorophenyl)methoxy]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole

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About This Item

Fórmula empírica (Notação de Hill):
C18H15Cl3N2O · HNO3
Número CAS:
24169-02-6
Peso molecular:
444.70
Número CE:
246-053-5
Número MDL:
MFCD00058160
Código UNSPSC:
51102829
ID de substância PubChem:
24894567
NACRES:
NA.85

Formulário

powder or crystals

Nível de qualidade

200

cor

white to off-white

espectro de atividade do antibiótico

Gram-positive bacteria
fungi

Modo de ação

cell membrane | interferes
cell wall synthesis | interferes
enzyme | inhibits

cadeia de caracteres SMILES

O[N+]([O-])=O.Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1

InChI

1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)

chave InChI

DDXORDQKGIZAME-UHFFFAOYSA-N

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Descrição geral

Chemical structure: imidazole

Aplicação

Econazole is a broad spectrum antimycotic similar to ketoconazole. It has some action against Gram positive bacteria. It is used topically in dermatomycoses as well as orally and parenterally. It is used for studies on processes such as platelet serotonin uptake, prostanoid biosynthesis, EDHF-mediated relaxation, and Ca2+ transport pathways in thymic lymphocytes.

Ações bioquímicas/fisiológicas

Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H315,H319

Classificações de perigo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
088M4084V
098M4025V
107M4039V
086M4065V
127M4032V

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Clinical microbiology reviews, 12(4), 501-517 (1999-10-09)
The increased use of antibacterial and antifungal agents in recent years has resulted in the development of resistance to these drugs. The significant clinical implication of resistance has led to heightened interest in the study of antimicrobial resistance from different
Alessandro Malara et al.
The Journal of biological chemistry, 292(8), 3239-3251 (2017-01-05)
Abscisic acid (ABA) is a phytohormone involved in pivotal physiological functions in higher plants. Recently, ABA has been proven to be also secreted and active in mammals, where it stimulates the activity of innate immune cells, mesenchymal and hematopoietic stem
C J Jackson et al.
FEMS microbiology letters, 192(2), 159-162 (2000-11-07)
Azole antifungals are central to therapy and act by inhibiting a cytochrome P450, sterol 14-demethylase and blocking normal sterol synthesis. Our recent identification of a mycobacterial sterol biosynthetic pathway led us to probe the efficacy of a range of these
Inhibition of Ca2+ transport pathways in thymic lymphocytes by econazole, miconazole, and SKF 96365
M. J. Mason, B. Mayer, et al.
American Journal of Physiology. Cell Physiology, 264, C654-C662 (1993)
Núria Daranas et al.
Applied and environmental microbiology, 84(10) (2018-03-11)
A viability quantitative PCR (v-qPCR) assay was developed for the unambiguous detection and quantification of Lactobacillus plantarum PM411 viable cells in aerial plant surfaces. A 972-bp region of a PM411 predicted prophage with mosaic architecture enabled the identification of a
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