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Key Documents

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E1279

Sigma-Aldrich

Enoximone

solid

Sinônimo(s):

1,3-Dihydro-4-methyl-5-(4-methylthiobenzoyl)-2H-imidazol-2-one

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About This Item

Fórmula empírica (Notação de Hill):
C12H12N2O2S
Número CAS:
77671-31-9
Peso molecular:
248.30
Número MDL:
MFCD00867130
Código UNSPSC:
41106305
ID de substância PubChem:
24278408
NACRES:
NA.77

forma

solid

cor

light yellow

solubilidade

DMSO: soluble 28 mg/mL

cadeia de caracteres SMILES

CSc1ccc(cc1)C(=O)C2=C(C)NC(=O)N2

InChI

1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16)

chave InChI

ZJKNESGOIKRXQY-UHFFFAOYSA-N

Informações sobre genes

human ... PDE3A(5139) , PDE3B(5140)

Ações bioquímicas/fisiológicas

Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.

Características e benefícios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análise (COA)

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S Schauvliege et al.
Equine veterinary journal, 41(8), 778-785 (2010-01-26)
No studies have been reported on the effects of enoximone in anaesthetised colic horses. To examine whether enoximone improves cardiovascular function and reduces dobutamine requirement in anaesthetised colic horses. Forty-eight mature colic horses were enrolled in this prospective, randomised clinical
H J Gilfrich et al.
Zeitschrift fur Kardiologie, 80 Suppl 4, 93-97 (1991-01-01)
Enoximone, a new phosphodiesterase-inhibitor with positive inotropic and vasodilating activities is available for intravenous use in patients with severe heart failure. A review of the current knowledge regarding the adverse effects of this substance reveals that they are characterized by
B Hausen et al.
European heart journal, 13(5), 679-686 (1992-05-01)
Inotropic support is often required for post-operative management of patients following mitral valve operation. The use of positive inotropes is limited by tolerance development and increase in myocardial oxygen demand. We have compared i.v. enoximone (E) (group E, n =
Paolo Nardi et al.
The Annals of thoracic surgery, 87(5), 1401-1407 (2009-04-22)
Coronary artery bypass grafting (CABG) is a well-accepted therapeutic strategy for patients with multivessel coronary artery disease and left ventricular dysfunction. The aim of the study was to evaluate long-term results after CABG in patients with preoperative left ventricular ejection
Stijn Schauvliege et al.
Veterinary anaesthesia and analgesia, 36(3), 197-208 (2009-04-29)
To compare cardiac output () measurements using lithium dilution (LiDCO) and pulse contour analysis (PulseCO) techniques in isoflurane-anaesthetized ponies before and during the administration of different inotropic/vasoactive drugs. Prospective randomized experimental cross-over trial. Six ponies aged 5.0 +/- 1.6 (4-6.5)
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Discover Bioactive Small Molecules for Cyclic Nucleotides

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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