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Merck
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Key Documents

Outros documentos

D4071

Sigma-Aldrich

5, 15-DPP

Sinônimo(s):

5,15-Diphenyl-21H,23H-porphine, 5,15-Diphenylporphyrin, 5,15-diphenyl-Porphine

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About This Item

Fórmula empírica (Notação de Hill):
C32H22N4
Número CAS:
22112-89-6
Peso molecular:
462.54
Número MDL:
MFCD08276335
Código UNSPSC:
12352200
ID de substância PubChem:
329798793
NACRES:
NA.77

forma

powder

Nível de qualidade

100

cadeia de caracteres SMILES

c1ccc(cc1)-c2c3ccc(cc4ccc([nH]4)c(-c5ccccc5)c6ccc(cc7ccc2[nH]7)n6)n3

InChI

1S/C32H22N4/c1-3-7-21(8-4-1)31-27-15-11-23(33-27)19-25-13-17-29(35-25)32(22-9-5-2-6-10-22)30-18-14-26(36-30)20-24-12-16-28(31)34-24/h1-20,33,36H/b23-19-,24-20-,25-19-,26-20-,31-27-,31-28-,32-29-,32-30-

chave InChI

FNNOEKVUXXVPAI-DUVOQLPESA-N

Aplicação

5, 15-DPP has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:
  • to analyze its effects on malignant peripheral nerve sheath tumor (MPNST) survival and proliferation
  • to study its effects on the thymic stromal lymphopoietin (TSLP) modulation of nometastatic gene 23-H1 (NME1 or nm23-H1) expression in human trophoblasts
  • to study its effects on 17β-estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced M2 polarization in human macrophages and endometrial stromal cells

Ações bioquímicas/fisiológicas

5, 15-DPP is a selective STAT3 inhibitor and a selective STAT3-SH2 antagonist

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Yun Wang et al.
PloS one, 10(5), e0125559-e0125559 (2015-05-08)
The goal of this study is to elucidate the effects of 17β-estradiol and TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) on macrophage phenotypes in the endometriotic milieu. Co-culture of endometrial stromal cells (ESCs) and U937 cells (macrophage cell line) was performed to simulate the endometriotic
Ying Wang et al.
Clinical immunology (Orlando, Fla.), 143(1), 88-95 (2012-03-01)
Our previous study has demonstrated that TSLP induces the invasion of human trophoblasts and plays a role in embryo implantation. The present study is undertaken to explore the mechanism by which TSLP modulates trophoblast invasion. It was revealed that TSLP
Jody Fromm Longo et al.
Cell communication and signaling : CCS, 17(1), 74-74 (2019-07-12)
We have found that erbB receptor tyrosine kinases drive Ras hyperactivation and growth in NF1-null malignant peripheral nerve sheath tumors (MPNSTs). However, MPNSTs variably express multiple erbB receptors with distinct functional characteristics and it is not clear which of these

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