D3900

Desipramine hydrochloride

≥98% (TLC), powder

• Fórmula empírica (Notação de Hill): C₁₈H₂₂N₂ · HCl
• Número CAS: 58-28-6
• Peso molecular: 302.84
• Número CE: 200-373-1
• Número MDL: MFCD00058108
• Código UNSPSC: 12352116
• ID de substância PubChem: 24278094
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (TLC)
• forma: powder
• cor: white to off-white
• solubilidade: H₂O: 50 mg/mL
• originador: Sanofi Aventis
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl[H].CNCCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
• chave InChI: XAEWZDYWZHIUCT-UHFFFAOYSA-N
• Informações sobre genes: human ... SLC6A2(6530)

Descrição

Descrição geral

Desipramine, a metabolite of imipramine and iofepramine is an active tricyclic antidepressant.

Aplicação

Desipramine hydrochloride has been used:

• to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
• to protect unselective damage to the noradrenergic system
• as a norepinephrine re-uptake inhibitor to treat rats for lesioning

Ações bioquímicas/fisiológicas

Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (K_i = 4 nM) than the serotonin transporter (K_i = 61 nM).

Características e benefícios

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Atenção

Hygroscopic

Informações de segurança

• Pictogramas: GHS07,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H302 - H315 - H317 - H319 - H334 - H335
• Declarações de precaução: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves