D0946
PDGFRα (550-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinônimo(s):
CD140A, MGC74795, Rhe-PDGFRA
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.32
Produtos recomendados
recombinante
expressed in baculovirus infected Sf9 cells
Nível de qualidade
linha de produto
PRECISIO® Kinase
Ensaio
≥70% (SDS-PAGE)
Formulário
buffered aqueous glycerol solution
atividade específica
10-14 nmol/min·mg
peso molecular
~95 kDa
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... PDGFRA(5156)
Ações bioquímicas/fisiológicas
PDGFRα (platelet-derived growth factor receptor α) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFRα has been linked to developmental abnormalities in vertebrate models and has been implicated in multiple disease states in humans. There is widespread expression of PDGFRα in renal cell types involved in fibrotic and sclerosing processes. PDGF and its receptor PDGFRα are inducers of fibrosis in the repair phase of inflammatory bowel disease and they may also be involved in the active inflammatory phase.
forma física
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Informações legais
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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J Floege et al.
Journal of the American Society of Nephrology : JASN, 9(2), 211-223 (1998-04-04)
Platelet-derived growth factor (PDGF) plays an important role in renal disease. We have recently demonstrated that in healthy mature human kidney, PDGF alpha-receptor expression is largely restricted to interstitial cells. The study presented here assesses the expression of PDGF alpha-receptor
S Kumagai et al.
The Tohoku journal of experimental medicine, 195(1), 21-33 (2002-01-10)
The aim of the present study is to clarify in situ expression of platelet-derived growth factor (PDGF) and its receptors in different phases of inflammatory bowel disease (IBD). Tissues samples were obtained from 20 patients with ulcerative colitis (UC) and
Ittai Fattal et al.
Immunology, 143(3), 374-380 (2014-05-14)
Pemphigus vulgaris (PV) is an autoimmune skin disease, which has been characterized by IgG autoantibodies to desmoglein 3. Here we studied the antibody signatures of PV patients compared with healthy subjects and with patients with two other autoimmune diseases with
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