C7861

Citalopram hydrobromide

≥98% (HPLC), powder, serotonin uptake inhibitor

• Sinônimo(s): 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
• Fórmula empírica (Notação de Hill): C₂₀H₂₁FN₂O · HBr
• Número CAS: 59729-32-7
• Peso molecular: 405.30
• Número CE: 261-890-6
• Número MDL: MFCD02101306
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278335
• NACRES: NA.77

Propriedades

• product name: Citalopram hydrobromide, ≥98% (HPLC)
• Nível de qualidade: 200
• Ensaio: ≥98% (HPLC)
• forma: powder
• solubilidade: chloroform: soluble; methanol: soluble
• originador: Forest Labs
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
• InChI: 1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
• chave InChI: WIHMBLDNRMIGDW-UHFFFAOYSA-N
• Informações sobre genes: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

Descrição

Descrição geral

Citalopram is a bicyclic phthalene derivative. It initiates serotonergic activity, which produces antidepressant action. Citalopram hydrobromide reverses memory impairment. It is used to treat obsessive compulsive disorder, panic disorder, sociophobia and premenstrual dysphoric disorder.

Aplicação

Citalopram hydrobromide has been used:

• to examine its effects on sirt mRNA and mammalian sirtuins (SIRT) expression in mice
• to monitor body temperature and antidepressant-like behavioral responses in the forced swim test for rats
• for 5-hydroxytryptamine (5-HT) competition uptake assays

Ações bioquímicas/fisiológicas

Potent and selective serotonin uptake inhibitor (K_i = 5.4 nM); antidepressant

Características e benefícios

This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302,H336,H361d,H412
• Declarações de precaução: P202 - P261 - P264 - P273 - P301 + P312 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3
• Órgãos-alvo: Central nervous system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)