C7374

CK-636

≥98% (HPLC)

• Sinônimo(s): CK-0944636; N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide
• Fórmula empírica (Notação de Hill): C₁₆H₁₆N₂OS
• Número CAS: 442632-72-6
• Peso molecular: 284.38
• Número MDL: MFCD03036245
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: peach to light pink
• solubilidade: DMSO: ≥20 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cc1[nH]c2ccccc2c1CCNC(=O)c3cccs3
• InChI: 1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7,10,18H,8-9H2,1H3,(H,17,19)
• chave InChI: ACAKNPKRLPMONU-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes.

CK-636 inhibits the activity of actin-related protein (Arp)2/3 complex; binds between Arp2 and Arp3, blocks movement of Arp2 and Arp3 into active conformations, inhibits ability to nucleate actin filaments.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable