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C6637

Sigma-Aldrich

Cytochalasin A from Drechslera dematioidea

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About This Item

Fórmula empírica (Notação de Hill):
C29H35NO5
Número CAS:
14110-64-6
Peso molecular:
477.59
Beilstein:
949521
Número CE:
237-964-9
Número MDL:
MFCD00005935
Código UNSPSC:
12352200
ID de substância PubChem:
24892882
NACRES:
NA.77

forma

powder

Nível de qualidade

200

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

C[C@@H]1CCCC(=O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O

InChI

1S/C29H35NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,23-24,26-27,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,23+,24+,26+,27-,29-/m1/s1

chave InChI

ZMAODHOXRBLOQO-TZVKRXPSSA-N

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Ações bioquímicas/fisiológicas

Cytochalasin A reacts with sulfhydryls, and inhibits growth and glucose transport in Saccharomyces. Cytochalasin A is an oxidizing analog of cytochalsin B.

Outras notas

Oxidized analog of cytochalasin B.

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palavra indicadora

Danger

Frases de perigo

H300 + H310 + H330,H361

Classificações de perigo

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificados de análise (COA)

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Kumiko Masai et al.
Bioscience, biotechnology, and biochemistry, 68(7), 1569-1573 (2004-07-28)
The distribution of the secreted protein ribonuclease T1 (RntA) fused with the enhanced green fluorescent protein (EGFP), RntA-EGFP, was visualized in hyphae of Aspergillus oryzae in the presence of a protein transport inhibitor, brefeldin A, cytochalasin A, or nocodazole. During
Naimeh Taheri-Talesh et al.
Molecular biology of the cell, 19(4), 1439-1449 (2008-01-25)
Hyphal tip growth in fungi is important because of the economic and medical importance of fungi, and because it may be a useful model for polarized growth in other organisms. We have investigated the central questions of the roles of
Zhe Sun et al.
American journal of physiology. Cell physiology, 295(1), C268-C278 (2008-05-23)
Integrin-mediated mechanotransduction in vascular smooth muscle cells (VSMCs) plays an important role in the physiological control of tissue blood flow and vascular resistance. To test whether force applied to specific extracellular matrix (ECM)-integrin interactions could induce myogenic-like mechanical activity at
Norio Takeshita et al.
Molecular biology of the cell, 16(4), 1961-1970 (2005-02-11)
One of the essential features of fungal morphogenesis is the polarized synthesis of cell wall components such as chitin. The actin cytoskeleton provides the structural basis for cell polarity in Aspergillus nidulans, as well as in most other eukaryotes. A
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Protoplasma, 249(1), 99-106 (2011-02-08)
Elucidating resistance mechanisms of plant cells against pathogens is essential to develop novel strategies of disease control. The actin cytoskeleton was found intimately involved in plant defense. In order to reveal how actin would be involved in the interaction between
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