C3545
Monoclonal Anti-Calmodulin antibody produced in mouse
clone 6D4, ascites fluid
Sinônimo(s):
Anti-CALM3, Anti-calmodulin
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About This Item
Produtos recomendados
fonte biológica
mouse
conjugado
unconjugated
forma do anticorpo
ascites fluid
tipo de produto de anticorpo
primary antibodies
clone
6D4, monoclonal
contém
15 mM sodium azide as preservative
reatividade de espécies
chicken, Dictyostelium discoideum, bovine, rat
técnica(s)
western blot: 1:2,000 using a bovine brain calmodulin preparation
Isotipo
IgG1
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
rat ... Calm1(24242)
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Descrição geral
Calmodulin belongs to a family of structurally homologous Ca2+-binding proteins. CALM1 gene is located on human chromosome 14q32.11.
Calmodulin is a highly conserved 17kDa calcium binding protein found in all eukaryotic cells. It is a multifunctional molecule. Monoclonal anti-Calmodulin (mouse IgG1 isotype) is derived from the 6D4 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with calmodulin, purified from Dictyostelium discoideum and conjugated to KLH.
Especificidade
The antibody recognizes native and SDS-denatured calmodulin.
These antibodies are directed against different epitopes within the calmodulin molecule.
Imunogênio
preparation of purified calmodulin from Dictyostelium discoideum conjugated to KLH.
Aplicação
Monoclonal Anti-Calmodulin antibody produced in mouse has been used in:
- enzyme-linked immunosorbent assay (ELISA)
- immunoblot
- dot blot
- immunocytochemistry
- immunoprecipitation
- immunofluorescence
Ações bioquímicas/fisiológicas
Calmodulin is a ubiquitous molecule which can bind up to 4 calcium ions, regulating and mediating a wide variety of biochemical processes.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Nº do produto
Descrição
Preços
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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C J Pallen et al.
The Journal of biological chemistry, 259(10), 6134-6141 (1984-05-25)
Calcineurin possesses phosphatase activity towards both protein (Stewart, A.A., Ingebritsen , T.S., Manalan , A., Klee , C.B., and Cohen, P. (1982) FEBS Lett. 137, 80-84) and nonprotein substrates ( Pallen , C.J., and Wang, J.H. (1983) J. Biol. Chem.
The intellectual disability-associated CAMK2G p. Arg292Pro mutation acts as a pathogenic gain-of-function
Proietti OM, et al.
Human Mutation, 39(12), 2008-2024 (2018)
Identification of calmodulin and MlcC as light chains for Dictyostelium myosin-I isozymes
Crawley SW, et al.
Biochemistry, 50(30), 6579-6588 (2011)
Association between the polymorphisms of CALM1 gene and osteoarthritis risk: a meta-analysis based on observational studies
Yang H, et al.
Bioscience Reports, 38(5), BSR20181128-BSR20181128 (2018)
D Hulen et al.
Cell motility and the cytoskeleton, 18(2), 113-122 (1991-01-01)
Monoclonal antibodies were raised against calmodulin purified from Dictyostelium discoideum. To increase its antigenicity, the calmodulin was conjugated to keyhole limpet hemocyanin; mice were immunized with the conjugate. Hybridomas producing antibodies against calmodulin were identified by screening culture supernatants with
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