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C0605

Sigma-Aldrich

Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone

≥90% (HPLC)

Sinônimo(s):

Z-DEVD-FMK

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About This Item

Fórmula empírica (Notação de Hill):
C30H41N4O12F
Número CAS:
210344-95-9
Peso molecular:
668.66
Número MDL:
MFCD23380217
Código UNSPSC:
12352200
ID de substância PubChem:
329774802

Ensaio

≥90% (HPLC)

Formulário

powder

cor

off-white

solubilidade

DMSO: ≥20 mg/mL, clear

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

COC(=O)CC[C@H](NC(=O)[C@H](CC(=O)OC)NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF

InChI

1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1

chave InChI

GBJVAVGBSGRRKN-JYEBCORGSA-N

Ações bioquímicas/fisiológicas

A cell-permeable inhibitor of caspase 3, 6, 7, 8, 10, which exhibits competitive and irreversible inhibition.

Características e benefícios

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
019K4618
027K1397
105K1133
055K1564
114K1445

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The progression from Barrett's metaplasia to adenocarcinoma is associated with the acquirement of an apoptosis-resistant phenotype. The bile acid deoxycholate (DCA) has been proposed to play an important role in the development of esophageal adenocarcinoma, but the precise molecular mechanisms
Ji-An Zhao et al.
Oncology letters, 12(5), 4252-4262 (2016-11-30)
Curcumin (CUR) has been demonstrated to protect against carcinogenesis and to prevent tumor development in cancer; however, the clinical application of CUR is limited by its instability and poor metabolic properties. The present study offers an strategy for a novel
Karianne Risberg et al.
PloS one, 6(9), e24012-e24012 (2011-09-15)
In cancer, combinations of drugs targeting different cellular functions is well accepted to improve tumor control. We studied the effects of a Pseudomonas exotoxin A (PE)-based immunotoxin, the 9.2.27PE, and the BH-3 mimetic compound ABT-737 in a panel of melanoma
Xiao Feng et al.
Cancer letters, 385, 12-20 (2016-11-09)
Vascular recovery or re-angiogenesis after radiotherapy plays a significant role in tumor recurrence, whereas molecular mechanisms of this process remain elusive. In this work, we found that dying glioma cells promoted post-irradiation angiogenesis through a caspase 3 dependent mechanism. Evidence
Jin Hwa Cho et al.
BMB reports, 46(12), 588-593 (2013-11-08)
Apoptosis, programmed cell death, is a process involved in the development and maintenance of cell homeostasis in multicellular organisms. It is typically accompanied by the activation of a class of cysteine proteases called caspases. Apoptotic caspases are classified into the
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