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Key Documents

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C0496

Sigma-Aldrich

CRT0044876

≥98% (HPLC)

Sinônimo(s):

7-Nitro-1H-indole-2-carboxylic acid, 7-Nitroindole-2carboxylic acid, NSC 69877

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About This Item

Fórmula empírica (Notação de Hill):
C9H6N2O4
Número CAS:
6960-45-8
Peso molecular:
206.15
Número CE:
230-154-6
Número MDL:
MFCD00044720
Código UNSPSC:
12352200
ID de substância PubChem:
329774800
NACRES:
NA.25

Ensaio

≥98% (HPLC)

forma

powder

solubilidade

DMSO: >20 mg/mL

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

OC(=O)c1cc2cccc([N+]([O-])=O)c2[nH]1

InChI

1S/C9H6N2O4/c12-9(13)6-4-5-2-1-3-7(11(14)15)8(5)10-6/h1-4,10H,(H,12,13)

chave InChI

BIUCOFQROHIAEO-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

CRT0044876 targets the apurinic endonuclease (APE1) active site and inhibits its 3′-phosphodiesterase and 3′-phosphatase activities—essential steps in excision repair—with minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentrations as high as 100 μM. At non-cytotoxic concentrations, CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds, with accumulation of apurinic sites.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Danger

Frases de perigo

H319,H334

Classificações de perigo

Eye Irrit. 2 - Resp. Sens. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análise (COA)

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Jeroen E J Guikema et al.
The Journal of experimental medicine, 204(12), 3017-3026 (2007-11-21)
Antibody class switch recombination (CSR) occurs by an intrachromosomal deletion requiring generation of double-stranded breaks (DSBs) in switch-region DNA. The initial steps in DSB formation have been elucidated, involving cytosine deamination by activation-induced cytidine deaminase and generation of abasic sites
Junqiu Zhai et al.
Nucleic acids research, 45(6), e45-e45 (2016-12-08)
Human apurinic/apyrimidinic endonuclease/redox effector factor 1 (APE1) is an essential DNA repair protein. Herein, we demonstrate that avidin-oriented abasic site-containing DNA strands (AP-DNA) on the surface of silica coated magnetic nanoparticles (SiMNP) can selectively respond to APE1 while resist the
De-Sheng Pei et al.
Nucleic acids research, 39(8), 3156-3165 (2010-12-22)
DNA repair is required to maintain genome stability in stem cells and early embryos. At critical junctures, oxidative damage to DNA requires the base excision repair (BER) pathway. Since early zebrafish embryos lack the major polymerase in BER, DNA polymerase
Lidan Li et al.
Nanoscale, 11(3), 1343-1350 (2019-01-04)
The transition of DNA nanomachines from test tubes to living cells would realize the ultimate goal of smart therapeutic dynamic DNA nanotechnology. The operation of DNA nanomachines in living cells remains challenging because it is difficult to utilize an endogenous
Prachi Verma et al.
Biochimie, 144, 122-133 (2017-11-04)
Dihydroxy-1-selenolane (DHS) previously reported to exhibit radioprotective activity was investigated to understand its mechanism of action in CHO cells of epithelial origin. DHS pre-treatment at 25 μM for 16 h significantly protected CHO cells from radiation (4-11 Gy)-induced delayed mitotic cell death. Further
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