AC-0362

ACTH (EP390) Rabbit Monoclonal Primary Antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• forma do anticorpo: Ig fraction of antiserum
• clone: monoclonal
• descrição: For In Vitro Diagnostic Use in Select Regions (See Chart)
• forma: buffered aqueous solution
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
• Isotipo: IgG
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C
• visualização: cytoplasmic

Descrição

Descrição geral

Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced from corticotropes in the anterior lobe of the pituitary gland. ACTH is released by corticotropin-releasing hormone stimulation by the hypothalamus in response to biological stress. Identifying ACTH is useful in the classification of pituitary tumors and diseases. Cushing′s disease derived from ACTH producing adenomas represents 10-15% of pituitary tumors. By immunohistochemistry (IHC), these tumors are immunoreactive for ACTH, beta-Lipotropin, and beta-endorphin. ACTH is also detected in a subset of growth hormone (GH), thyroid-stimulating hormone (TSH) and follicle-stimulating hormone (FSH) secreting adenomas. With the exception for ACTH secreting adenomas, most functioning adenomas are usually macroadenomas; tumors larger than 10 mm. A combination of ACTH IHC and reticulin staining also provides utility in the differential diagnosis between pituitary adenoma versus corticotroph hyperplasia. Breakdown of acinar structure and ACTH immunoreactivity are suggestive of adenoma.

Qualidade

IVD

IVD

IVD

RUO

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and &lt0.1% Sodium Azide

Outras notas

For a copy of the IFU and CofA contact IVDorder@ABCAM.com

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable