About This Item
Fórmula empírica (Notação de Hill):
C15H18O2
Número CAS:
Peso molecular:
230.30
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.25
Produtos recomendados
Nível de qualidade
Ensaio
≥98% (HPLC)
Formulário
powder or crystals
solubilidade
methanol: 1 mg/mL, clear, colorless
aplicação(ões)
metabolomics
vitamins, nutraceuticals, and natural products
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
C=C1CCC[C@@](C=C2O3)(C)[C@@]1([H])CC2=C(C)C3=O
InChI
1S/C15H18O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h8,12H,1,4-7H2,2-3H3/t12-,15+/m0/s1
chave InChI
ZTVSGQPHMUYCRS-SWLSCSKDSA-N
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Descrição geral
Atractylenolide I is one of the active ingredients of Rhizoma Atractylodes macrocephala which is obtained from the dried root and stem of Atractylodes Macrocephala Koidz. It is a sesquiterpene compound of hydrophobic nature.
Aplicação
Atractylenolide I is a phytochemical that may be used to study its anti-inflammatory and anti-angiogenesis activities. Atractylenolide I may be used and studied as a postitive modulator of GABA-induced chloride currents I(GABA) and as an inhibitor of aromatases. Atractylenolide I may be used as a reference material in assays to detect its presence in plant root extracts and biological milieu such as plasma.
Ações bioquímicas/fisiológicas
Atractylenolide I has been reported to have an anti-inflammatory activity due to its inhibitory effect on tumor necrosis factor-α (TNF-α) and the production of nitric oxide (NO). It also shows anti-cancer nature, thereby being used in the management of gastric cancer cachexia symptoms. Additionally, it has anti-angiogenic, pro-oxidative and cytotoxic characteristics.
Phytochemical from Traditional Chinese Medicine herbal preparations. Atractylenolide I is an anti-inflammatory that is reported to inhibit angiogenesis.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
339.6 °F
Ponto de fulgor (°C)
170.87 °C
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Judith Singhuber et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(3-4), 334-340 (2011-11-29)
Several Chinese herbal medicines (CHMs) are used in the treatment of insomnia, restlessness, or anxiety. However, mechanisms underlying this effect and scientific proof for their traditional use is scarce. In the present study CHMs were screened for their ability to
Hyun Young Park et al.
Planta medica, 77(13), 1528-1530 (2011-02-25)
The roots of Cyathula officinalis Kuan are widely used in Chinese medicine for the treatment of inflammatory disorders. Here, the ability of C. officinalis Kuan to downregulate matrix metalloproteinase (MMP)-13 was examined since MMP-13 is an important enzyme for the
Jian-Ming Huang et al.
Scientific reports, 4, 3840-3840 (2014-01-24)
Paclitaxel, a known TLR4 ligand, leads to activation of TLR4/MyD88-dependent pathway that mediates chemoresistance and tumor progression in epithelial ovarian carcinoma (EOC). Atractylenolide-I (AO-I), a novel TLR4-antagonizing agent, inhibits TLR4 signaling by interfering with the binding of LPS or paclitaxel
Yujuan Li et al.
Journal of pharmaceutical and biomedical analysis, 58, 172-176 (2011-10-22)
A new high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) was developed for quantitative analysis of atractylenolide I in rat plasma using buspirone as internal standard (I.S.). Rat plasma samples were deproteined with methanol and acetonitrile (1:1, v/v). Atractylenolide I and I.S.
Hai Jiang et al.
Molecules (Basel, Switzerland), 16(4), 3146-3151 (2011-04-16)
Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I, atractylenolide II and atractylenolide III had inhibition ratios of
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