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53467

Sigma-Aldrich

2,3-Dioleyloxy-1-(dimethylamino)propane

≥98.0% (TLC)

Sinônimo(s):

1,2-Dioleyloxy-3-(dimethylamino)propane, N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine, DODMA

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About This Item

Fórmula empírica (Notação de Hill):
C41H81NO2
Número CAS:
104162-47-2
Peso molecular:
620.09
Beilstein:
10139013
Número MDL:
MFCD22200991
Código UNSPSC:
12352211
ID de substância PubChem:
329757947
NACRES:
NA.85

fonte biológica

synthetic

Nível de qualidade

100

Ensaio

≥98.0% (TLC)

Formulário

liquid

grupo funcional

amine
ether

tipo de lipídio

cationic lipids

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CCCCCCCC\C=C/CCCCCCCCOCC(CN(C)C)OCCCCCCCC\C=C/CCCCCCCC

InChI

1S/C41H81NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,41H,5-18,23-40H2,1-4H3/b21-19-,22-20-

chave InChI

GLGLUQVVDHRLQK-WRBBJXAJSA-N

Categorias relacionadas

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
BCCG5373
BCCF3330
BCCB7309
BCCB3010
BCBZ6944

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Sigma-Aldrich

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Sigma-Aldrich

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Lloyd B Jeffs et al.
Pharmaceutical research, 22(3), 362-372 (2005-04-20)
A fully scalable and extrusion-free method was developed to prepare rapidly and reproducibly stabilized plasmid lipid particles (SPLP) for nonviral, systemic gene therapy. Liposomes encapsulating plasmid DNA were formed instantaneously by mixing lipids dissolved in ethanol with an aqueous solution
Yujing Li et al.
Nanomedicine : nanotechnology, biology, and medicine, 13(2), 371-381 (2016-10-18)
Microfluidic systems can accelerate clinical translation of nanoparticles due to their ability to generate nanoparticles in a well-controlled and reproducible manner. In this study, a single-step process based on microfluidic focusing (MF) was employed to synthesize transferrin-conjugated lipid nanoparticles (Tf-LNPs)
Adam Judge et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 13(2), 328-337 (2005-11-09)
The systemic application of nucleic acid drugs requires delivery systems that overcome the poor pharmacokinetics, limited biodistribution, and inefficient uptake of nucleic acids. PEGylated liposomes show considerable promise because of their intrinsic ability to accumulate at disease sites and facilitate
Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids.
Heyes, J., et al.
J. Controlled Release, 107, 276-287 (2005)
Xi Wang et al.
Molecules (Basel, Switzerland), 24(19) (2019-10-03)
Glioma is one of the most aggressive and common malignant brain tumors. Due to the presence of the blood-brain barrier (BBB), the effectiveness of therapeutics is greatly affected. In this work, to develop an efficient anti-glioma drug with targeting and
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