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Key Documents

422R-1

Sigma-Aldrich

PHOX2B (EP312) Rabbit Monoclonal Primary Antibody

Sinônimo(s):

Paired-like Homeobox 2B

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About This Item

Código UNSPSC:
12352203

fonte biológica

rabbit

Nível de qualidade

100
500

conjugado

unconjugated

forma do anticorpo

culture supernatant

tipo de produto de anticorpo

primary antibodies

clone

EP312, monoclonal

descrição

For In Vitro Diagnostic Use in Select Regions

forma

buffered aqueous solution

reatividade de espécies

human

embalagem

vial of 0.1 mL concentrate (422R-14)
vial of 0.1 mL concentrate Research Use Only (422R-14-RUO)
vial of 0.5 mL concentrate (422R-15)
vial of 1.0 mL concentrate (422R-16)
vial of 1.0 mL concentrate Research Use Only (422R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (422R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (422R-17)
vial of 7.0 mL pre-dilute ready-to-use (422R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (422R-18-RUO)

fabricante/nome comercial

Cell Marque

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

Isotipo

IgG

controle

neuroblastoma

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

visualização

nuclear

Informações sobre genes

human ... PHOX2B(8929)

Descrição geral

Paired-like homeobox 2B (PHOX2B) is a transcription factor located on chromosome 4p13 which is crucial to the formation of autonomic ganglia in the autonomic nervous system (ANS). PHOX2B gene is strictly expressed in neural crest derivatives committed to the noradrenergic phenotype. The PHOX2B gene encodes a paired-like homeo-domain transcription factor with an extra-axial expression pattern restricted to the ANS. Neuroblasts of peripheral neuroblastic tumors are derived from the sympathoadrenal lineage, a division of the ANS. PHOX2B has been observed in peripheral neuroblastic tumors, neuroblastomas, paragangliomas, ganglioneuroblastomas, ganglioneuromas and pheochromocytomas. PHOX2B has been reported to be negative in other small round blue cell tumors.

Qualidade


IVD

IVD

IVD

RUO

Ligação

PHOX2B Positive Control Slides, Product No. 422S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparo

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Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Daisuke Nonaka et al.
The American journal of surgical pathology, 37(8), 1236-1241 (2013-05-30)
Autonomic neurons and chromaffin cells, which constitute the autonomic nervous system, are derived from a common progenitor from the neural crest, and its development is controlled by a network of transcription factors, including the master regulator, Phox2b, and its downstream
A Pattyn et al.
Nature, 399(6734), 366-370 (1999-06-09)
The sympathetic, parasympathetic and enteric ganglia are the main components of the peripheral autonomic nervous system, and are all derived from the neural crest. The factors needed for these structures to develop include the transcription factor Mash1, the glial-derived neurotrophic

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