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406OA-05A

Sigma-Aldrich

Human Osteoblasts-Osteoarthritis: HOb-OA, adult

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About This Item

Código UNSPSC:
41106514
NACRES:
NA.81

fonte biológica

human bone (osteoarthritic)

Nível de qualidade

100

embalagem

pkg of 500,000 cells

fabricante/nome comercial

Cell Applications, Inc

modo de crescimento

Adherent

cariótipo

2n = 46

morfologia

osteoblast

técnica(s)

cell culture | mammalian: suitable

doença(s) relevante(s)

arthritis

Condições de expedição

dry ice

temperatura de armazenamento

−196°C

Categorias relacionadas

Descrição geral

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Human Osteoblasts-Osteoarthritis, HOb-OA, are isolated from bone of patients with osteoarthritis (OA) and provide an excellent model system to study the patophisiology of that disease in vitro, including matrix mineralization, effects of inflammatory mediators and bone morphogenic proteins, physiological control of bone remodeling and regulation of bone metabolism.

Characterization: Positive for bone mineralization.

Origem de linhagem celular

Bone

Aplicação

model system to study the pathophisiology of osteoarthritis, matrix mineralization, effects of inflammatory mediators, bone morphogenic proteins, bone remodeling and metabolism

Componentes

Basal Medium containing 10% FBS & 10% DMSO

Nota de preparo

  • 2nd passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO
  • Can be cultured at least 10 doublings

Rotina de subcultura

Please refer to the HOb-OA Culture Protocol.

Exoneração de responsabilidade

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Xiangxiang Sun et al.
International journal of biological sciences, 16(6), 994-1009 (2020-03-07)
Osteoarthritis (OA) is a common type of arthritis. Chronic inflammation is an important contributor to the pathogenesis of OA. The maturation and secretion of proinflammatory cytokines are controlled by inflammasomes, especially NLRP1 (NLR Family Pyrin Domain Containing 1) and NLRP3.

Protocolos

Human Osteoblasts Osteoarthritis (HOb-OA) Culture Protocol

Store the cryovials in a liquid nitrogen storage tank immediately upon arrival.

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