Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos Principais

359A-1

Sigma-Aldrich

Claudin 1 Rabbit Polyclonal Antibody

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Código UNSPSC:
12352203
NACRES:
NA.41
clone:
polyclonal
application:
IHC (p)
reatividade de espécies:
human
técnica(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
citations:
6

fonte biológica

rabbit

Nível de qualidade

100
500

conjugado

unconjugated

forma do anticorpo

Ig fraction of antiserum

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

descrição

For In Vitro Diagnostic Use in Select Regions (See Chart)

Formulário

buffered aqueous solution

reatividade de espécies

human

embalagem

vial of 0.1 mL concentrate (359A-14)
vial of 0.5 mL concentrate (359A-15)
bottle of 1.0 mL predilute (359A-17)
vial of 1.0 mL concentrate (359A-16)
bottle of 7.0 mL predilute (359A-18)

fabricante/nome comercial

Cell Marque™

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

controle

colon carcinoma, neurofibroma

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

visualização

membranous

Informações sobre genes

human ... CLDN1(9076)

Descrição geral

The claudins are a family of over twenty proteins which are components of tight junctions. Tight junctions are specialized regions of cell-to-cell contact made up of a network of strands to act as a molecular ‘gasket′ for preventing the leakage of ions, water, etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. The claudins constitute a variable component, with specific claudins being associated with specific tissues. The immunoreactivity for anti-claudin 1 is membranous and is found in nearly all carcinomas. The staining is much stronger in the carcinoma cells than in normal tissues. Anti-claudin 1 in a panel of immunostains that includes antibodies against EMA (positive), S-100 (negative), and GLUT1 can be utilized as a robust marker in the diagnosis of perineurioma and neurofibroma. Some studies have shown anti-claudin 1 to be a specific marker for meningiomas. Therefore, anti-claudin 1 with anti-EMA, anti-S-100 protein, anti-CD34, and anti-glial fibrillary acidic protein (GFAP) may be helpful in the differentiation of meningiomas from histologic mimics.

Qualidade


IVD
IVD
IVD
RUO

Ligação

Claudin 1 Positive Control Slides, Product No. 359S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Não está encontrando o produto certo?  

Experimente o nosso Ferramenta de seleção de produtos.

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
0000288558
0000288558

Não está vendo a versão correta?

Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Jason L Hornick et al.
The American journal of surgical pathology, 29(7), 845-858 (2005-06-17)
Perineuriomas are uncommon benign peripheral nerve sheath tumors that include soft tissue, sclerosing, and intraneural variants. Fewer than 50 soft tissue perineuriomas have been reported to date, and the clinical significance of atypical histologic features is unknown. To characterize these
J Roulson et al.
Histopathology, 47(6), 551-559 (2005-12-06)
The autopsy is in decline, despite the fact that accurate mortality statistics remain essential for public health and health service planning. The falling autopsy rate combined with the Coroners Review and Human Tissue Act have contributed to this decline, and
M E F Smith et al.
Histopathology, 47(6), 575-581 (2005-12-06)
To investigate the differentiation pattern of epithelioid sarcoma in terms of perineurial and endothelial differentiation, and its relationship to that of meningioma. Nine cases of epithelioid sarcoma and five cases of meningioma were studied in an immunohistochemical analysis of 'perineurial'
Ricardo S Macarenco et al.
Archives of pathology & laboratory medicine, 131(4), 625-636 (2007-04-12)
Perineuriomas are benign peripheral nerve sheath neoplasms composed of perineurial cells with characteristic immunohistochemical and ultrastructural features. They have been traditionally classified into two main types according to their location--intraneural and extraneural--and overlap histologically with many other tumors, which may
Andrew L Folpe et al.
The American journal of surgical pathology, 26(12), 1620-1626 (2002-12-03)
Perineuriomas are rare benign soft tissue tumors having an immunophenotype paralleling the normal perineurial cell [S-100 protein negative and epithelial membrane antigen (EMA) positive]. Because EMA expression in perineuriomas may be focal and/or faint, there is continued interest in the
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica