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23120

Sigma-Aldrich

α-Chloralose

≥98.0% (chloralose, AT)

Sinônimo(s):

1,2-O-(2,2,2-Trichloroethylidene)-α-D-glucofuranose, Anhydro-D-glucochloral, Chloralose

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About This Item

Fórmula empírica (Notação de Hill):
C8H11Cl3O6
Número CAS:
15879-93-3
Peso molecular:
309.53
Beilstein:
85418
Número CE:
240-016-7
Número MDL:
MFCD00005542
Código UNSPSC:
12352201
ID de substância PubChem:
57648022
NACRES:
NA.21

Nível de qualidade

100

Ensaio

≥98.0% (chloralose, AT)

Formulário

powder

atividade óptica

[α]20/D +17±2°, 5 hr, c = 2% in ethanol

Impurezas

15% Beta-chloralose

pf

178-184 °C

solubilidade

water: soluble 1 gm in 225 ml at 15 °C
chloroform: slightly soluble
diethyl ether: soluble
glacial acetic acid: soluble
petroleum ether: insoluble

cadeia de caracteres SMILES

OC[C@@H](O)[C@H]1O[C@@H]2O[C@@H](O[C@@H]2[C@H]1O)C(Cl)(Cl)Cl

InChI

1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1

chave InChI

OJYGBLRPYBAHRT-IPQSZEQASA-N

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Ações bioquímicas/fisiológicas

α-Chloralose stimulates the gama-aminobutyric acid (GABA)-induced chloride conductance of gama-aminobutyric acidA (GABAA) receptors expressed in Xenopus laevis oocytes.

Componentes

mixture of isomers of ~85% α-chloralose; ~15% β-chloralose

Outras notas

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Pictogramas

Skull and crossbonesEnvironment
GHS06,GHS09

Palavra indicadora

Danger

Frases de perigo

H301,H332,H336,H410

Classificações de perigo

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 3

Órgãos-alvo

Central nervous system

Código de classe de armazenamento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
BCCF1953
BCCC7714
BCCC5785
BCCB9674
BCCB0141

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R W Gear et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(16), 7175-7181 (1999-08-06)
We tested the hypothesis that noxious stimuli induce pain modulation by activation of supraspinal structures. We found that intense noxious stimuli (i.e., subdermal injection of capsaicin or paw immersion in hot water) induced profound attenuation of the jaw-opening reflex in
K M Garrett et al.
The Journal of pharmacology and experimental therapeutics, 285(2), 680-686 (1998-05-15)
alpha-Chloralose is widely used as an anesthetic in the laboratory due to its minimal effects on autonomic and cardiovascular systems, yet little is known about its mechanism of action. We examined the effects of alpha-chloralose on gamma-aminobutyric acid type A
Mingming Zhu et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 179(6), 701-710 (2009-03-12)
Direct measurements of deep-brain and body-core temperature were performed on rats to determine the influence of cerebral blood flow (CBF) on brain temperature regulation under static and dynamic conditions. Static changes of CBF were achieved using different anesthetics (chloral hydrate
Hongxia Lei et al.
Journal of neuroscience research, 88(2), 413-419 (2009-09-12)
Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the case of (1)H
Renata F Leoni et al.
NeuroImage, 58(1), 75-81 (2011-06-29)
Hypertension afflicts 25% of the general population and over 50% of the elderly. In the present work, arterial spin labeling MRI was used to non-invasively quantify regional cerebral blood flow (CBF), cerebrovascular resistance and CO(2) reactivity in spontaneously hypertensive rats
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