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Y0001208

Sinomenine

European Pharmacopoeia (EP) Reference Standard

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About This Item

Fórmula empírica (Notação de Hill):
C19H23NO4
Número CAS:
115-53-7
Peso molecular:
329.39
Código UNSPSC:
41116107
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

sinomenine

fabricante/nome comercial

EDQM

controle de medicamentos

regulated under CDSA - not available from Sigma-Aldrich Canada

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[Cl-].[N+H]1([C@@H]2[C@@H]3[C@@](CC1)(CC(=O)C(=C3)OC)c4c(ccc(c4O)OC)C2)C

InChI

1S/C19H23NO4.ClH/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19;/h4-5,9,12-13,22H,6-8,10H2,1-3H3;1H/t12-,13+,19-;/m1./s1

chave InChI

YMEVIMJAUHZFMW-VUIDNZEBSA-N

Categorias relacionadas

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Sinomenine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H315,H319,H335

Declarações de precaução

P301 + P312 + P330 - P305 + P351 + P338

Classificações de perigo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Quanxing Wang et al.
International immunopharmacology, 11(3), 373-376 (2010-11-27)
Sinomenine (SN), a pure compound extracted from the Sinomenium acutum plant, has been found to inhibit T- and B-lymphocyte activation, proliferation and function and to interfere with the differentiation, recruitment and function of several other cell types, such as dendritic
Qing-Feng Kong et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 30(20), 1573-1576 (2006-01-21)
To further understand sinomenine, this paper has introduced the abstract technology, assaying, pharmaceutical chemistry, pharmacological action, pharmacotoxicology, pharmacokinetics and clinical application of sinomenine based on the important and significant contents of reference which have been consulted in the past ten
Zhao Yang et al.
Molecular immunology, 60(2), 109-114 (2014-05-13)
Intracerebral hemorrhage (ICH) causes morbidity and mortality and commonly follows the reperfusion after an ischemic event. Microglial activation mediated cytokine and protease secretion contributes to brain injury in ICH. Previous studies have shown that sinomenine possesses potent immunoregulatory properties. However
Min Xu et al.
Planta medica, 74(12), 1423-1429 (2008-08-07)
Sinomenine (SIN), an alkaloid isolated from CAULIS SINOMENII, has been used in the treatment of rheumatoid arthritis (RA) clinically. This study aimed to systematically evaluate the efficacy and safety of SIN by a comparison between SIN and non-steroidal anti-inflammatory drugs
[Research advances of mechanism of sinomenine in treating rheumatoid arthritis].
Yong-Li Zhang et al.
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 7(8), 775-778 (2009-08-13)

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