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Y0000838

Doxepin hydrochloride

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C19H21NO · HCl
Número CAS:
1229-29-4
Peso molecular:
315.84
Número MDL:
MFCD00079135
Código UNSPSC:
41116107
ID de substância PubChem:
329831184
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

doxepin

fabricante/nome comercial

EDQM

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl[H].CN(C)CC\C=C1/c2ccccc2COc3ccccc13

InChI

1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;

chave InChI

MHNSPTUQQIYJOT-SJDTYFKWSA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Doxepin hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

produto relacionado

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Descrição
Preços

Y0000851

Doxepin for system suitability, European Pharmacopoeia (EP) Reference Standard

1225511

Doxepin Related Compound A, United States Pharmacopeia (USP) Reference Standard

1225500

Doxepin hydrochloride, United States Pharmacopeia (USP) Reference Standard

1225522

Doxepin Related Compound B, United States Pharmacopeia (USP) Reference Standard

1225533

Doxepin Related Compound C, United States Pharmacopeia (USP) Reference Standard

BP136

Doxepin hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP823

Doxepin impurity standard, British Pharmacopoeia (BP) Reference Standard

PHR8923

Doxepin Related Compound C

PHR8924

Doxepin Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Haramandeep Singh et al.
Expert opinion on investigational drugs, 16(8), 1295-1305 (2007-08-10)
Low-dose doxepin hydrochloride (1, 3 and 6 mg) is a tricyclic antidepressant currently being investigated for the treatment of primary insomnia in adult and geriatric patients. Although it has been used at much higher doses to treat depression effectively for
Grzegorz Jagla et al.
Pharmacological reports : PR, 66(3), 459-465 (2014-06-07)
The therapy of neuropathic pain may include the use of co-analgesics, such as antidepressants, however, their desired analgesic effect is associated with significant side effects. An alternative approach to this is their local administration which has been proposed, but there
Alvaro Gimeno et al.
International journal of pharmaceutics, 477(1-2), 650-654 (2014-12-03)
According to previous studies reporting the anesthetic/analgesic action of oral topical doxepin administration, this study evaluated a model of buccal permeation to determine the depth of delivery of doxepin into excised porcine buccal mucosa following topical application of a saturated
Shigeru Hishinuma et al.
Biochemical pharmacology, 91(2), 231-241 (2014-07-30)
Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human

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