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Y0000747

Moxidectin for system suitability

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

Moxidectin

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About This Item

Fórmula empírica (Notação de Hill):
C37H53NO8
Número CAS:
113507-06-5
Peso molecular:
639.82
Número MDL:
MFCD00866560
Código UNSPSC:
41116107
ID de substância PubChem:
329831127
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

moxidectin

fabricante/nome comercial

EDQM

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CO\N=C1/C[C@]2(C[C@@H]3CC(C\C=C(C)\C[C@@H](C)\C=C\C=C4/COC5[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]45O)O2)O[C@@H]([C@H]1C)\C(C)=C\C(C)C

InChI

1S/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31+/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1

chave InChI

YZBLFMPOMVTDJY-LSGXYNIPSA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Moxidectin for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Pictogramas

Skull and crossbonesEnvironment
GHS06,GHS09

Palavra indicadora

Danger

Frases de perigo

H301,H400

Classificações de perigo

Acute Tox. 3 Oral - Aquatic Acute 1

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

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Lot/Batch Number

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Atul Awasthi et al.
Profiles of drug substances, excipients, and related methodology, 38, 315-366 (2013-05-15)
Moxidectin or F28249α is a potent endectocide and semisynthetic methoxime derivative of naturally occurring nemadectin. It is well known for the novel mode of action against a broad range of nematode and anthropod animal parasites. In this work, physicochemical and
Meenakshi Verma et al.
Folia parasitologica, 61(6), 561-570 (2015-02-06)
Moxidectin is a macrocyclic lactone belonging to milbemycin family closely related to ivermectin and is currently progressing towards Phase III clinical trial against human infection with the filaria Onchocerca volvulus (Leuckart, 1894). There is a single report on the microfilaricidal
Extralabel use of ivermectin and moxidectin in food animals.
R E Baynes et al.
Journal of the American Veterinary Medical Association, 217(5), 668-671 (2000-09-08)
Till F Omansen et al.
PLoS neglected tropical diseases, 9(3), e0003549-e0003549 (2015-03-06)
Mycobacterium ulcerans causes Buruli ulcer (BU), a debilitating infection of subcutaneous tissue. There is a WHO-recommended antibiotic treatment requiring an 8-week course of streptomycin and rifampicin. This regime has revolutionized the treatment of BU but there are problems that include
Bob Storey et al.
International journal for parasitology. Drugs and drug resistance, 4(3), 233-243 (2014-12-18)
A major hindrance to evaluating nematode populations for anthelmintic resistance, as well as for screening existing drugs, new compounds, or bioactive plant extracts for anthelmintic properties, is the lack of an efficient, objective, and reproducible in vitro assay that is

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