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Key Documents

Y0000146

Nadolol

European Pharmacopoeia (EP) Reference Standard

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About This Item

Fórmula empírica (Notação de Hill):
C17H27NO4
Número CAS:
Peso molecular:
309.40
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

nadolol

fabricante/nome comercial

EDQM

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC(C)(C)NCC(O)COc1cccc2C[C@@H](O)[C@@H](O)Cc12

InChI

1S/C17H27NO4/c1-17(2,3)18-9-12(19)10-22-16-6-4-5-11-7-14(20)15(21)8-13(11)16/h4-6,12,14-15,18-21H,7-10H2,1-3H3/t12?,14-,15+/m1/s1

chave InChI

VWPOSFSPZNDTMJ-UCWKZMIHSA-N

Informações sobre genes

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Nadolol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Nadolol: a new beta-adrenoceptor antagonist.
W H Frishman
The New England journal of medicine, 305(12), 678-682 (1981-09-17)
R C Heel et al.
Drugs, 20(1), 1-23 (1980-07-01)
Nadolol is a nonselective beta-adrenoceptor blocking drug without intrinsic sympathomimetic or membrane stabilising activity. Its inherently long duration of activity makes it suitable for once daily administration in both hypertension and angina pectoris, and in these conditions it has been
Zsuzsa Jenei-Lanzl et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(9), 2472-2481 (2014-05-14)
Mesenchymal progenitor cell chondrogenesis is the biologic platform for the generation or regeneration of cartilage, but the external influence of the sympathetic nervous system on this process is not yet known. Sympathetic nerve fibers are present in articular tissue, and
Rosa Adriana Jarillo-Luna et al.
Journal of neuroimmunology, 278, 223-231 (2014-12-04)
Stress stimuli affect the immune system of the mucosa, and in particular IgA secretion. It is well documented that intense psychological and physical stress can increase susceptibility to infection by diverse pathogens in the upper respiratory tract. Our workgroup reported
S Misaka et al.
Clinical pharmacology and therapeutics, 95(4), 432-438 (2014-01-15)
This study aimed to evaluate the effects of green tea on the pharmacokinetics and pharmacodynamics of the β-blocker nadolol. Ten healthy volunteers received a single oral dose of 30 mg nadolol with green tea or water after repeated consumption of green

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