PHR1975

Dextromethorphan Impurity C

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinônimo(s): (9α,13α,14α)-3-Methoxy-17-methylmorphinan-10-one, 10-Keto dextromethorphan
• Fórmula empírica (Notação de Hill): C₁₈H₂₃NO₂
• Número CAS: 57969-05-8
• Peso molecular: 285.38
• Código UNSPSC: 41116107
• NACRES: NA.24

Propriedades

• grau: certified reference material; pharmaceutical secondary standard
• Nível de qualidade: 300
• Agency: traceable to USP 1181040
• Certificado de análise (CofA): current certificate can be downloaded
• embalagem: pkg of 30 mg
• aplicação(ões): pharmaceutical
• formato: neat
• temperatura de armazenamento: 2-30°C
• InChI: 1S/C18H23NO2/c1-19-10-9-18-8-4-3-5-14(18)16(19)17(20)13-7-6-12(21-2)11-15(13)18/h6-7,11,14,16H,3-5,8-10H2,1-2H3/t14-,16-,18+/m1/s1
• chave InChI: UOCRGKKCNCIQCZ-KYJSFNMBSA-N

Descrição

Descrição geral

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Aplicação

• Pharmacokinetic Study of Alpha-Hydroxytriazolam: Research involving the urinary excretion of alpha-hydroxytriazolam after a single dose of Halcion provides insights into the metabolic pathways and elimination characteristics of this benzodiazepine derivative. Using α-Hydroxytriazolam-d₄ as an internal standard in mass spectrometry enhances the accuracy of such studies, which is critical for understanding the drug′s behavior in the human body and for developing therapeutic guidelines (Lin et al., 2005).


• Confirmation of Urinary Benzodiazepine Metabolites: A study that utilizes gas chromatography-mass spectrometry (GC-MS) to confirm the presence of urinary benzodiazepine metabolites, including α-Hydroxytriazolam, emphasizes the role of α-Hydroxytriazolam-d₄ as a vital analytical standard. This research aids in forensic toxicology and clinical diagnostics by providing robust methodologies for the detection and quantification of benzodiazepines in biological samples (Meatherall, 1994).

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAB3994 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301,H336
• Declarações de precaução: P261 - P264 - P270 - P271 - P301 + P310 - P304 + P340 + P312
• Classificações de perigo: Acute Tox. 3 Oral - STOT SE 3
• Órgãos-alvo: Central nervous system
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable