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Key Documents

PHR1475

Supelco

Disodium Inosinate

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

Inosine 5′-monophosphate disodium salt hydrate, 5′-IMP-Na2, 5′-Inosinic acid disodium salt hydrate, I-5′-P, IMP, Inosinic Acid

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About This Item

Fórmula empírica (Notação de Hill):
C10H11N4O8PNa2 · xH2O
Número CAS:
Peso molecular:
392.17 (anhydrous basis)
Número CE:
Número MDL:
Código UNSPSC:
41116107
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to USP 1222002

família API

disodium inosinate

Certificado de análise (CofA)

current certificate can be downloaded

embalagem

pkg of 1 g

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])([O-])=O)n2cnc3C(=O)NC=Nc23

InChI

1S/C10H13N4O8P.2Na.H2O/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;;/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

chave InChI

KQCIGEIXDXQSGM-MSQVLRTGSA-L

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Descrição geral

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Disodium inosinate is the disodium salt of inosinic acid which belongs to the group of purine-5′-nucleotides. It is generally used as a taste and flavor enhancer in foods to provide umami taste.

Aplicação

Disodium inosinate may be used as a pharmaceutical reference standard for the determination of the analyte in raw materials and food products by spectrophotometry, and chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Ações bioquímicas/fisiológicas

Inosine monophosphate, or inosinic acid, is the ribonucleotide of hypoxanthine and the first nucleotide formed during purine synthesis.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAA3023 in the slot below. This is an example certificate only and may not be the lot that you receive.

produto relacionado

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Development of purity reference material of disodium inosinate [J]
GAO YH, et al.
China Measurement and Testing, 6 (2009)
Taste perception and Integration
Flavor, 101-119 (2016)
Simultaneous UV-Spectrophotometric Determination of disodium 5?-inosinate and Disodium 5?-guanylate in tasty flavourings with calibration by the method of Principal Component Regression [J]
Shan YE
Physical Testing and Chemical Analysis Part B:Chemical Analysis, 7 (2010)
Determination of IMP and GMP in Flavor Nucleotides by HPLC [J]
LI YJ, et al.
Chinese Journal of Experimental Medical Formulae, 7 (2012)
Bochuan Teng et al.
Current biology : CB, 29(21), 3647-3656 (2019-09-24)
The sense of taste allows animals to sample chemicals in the environment prior to ingestion. Of the five basic tastes, sour, the taste of acids, had remained among the most mysterious. Acids are detected by type III taste receptor cells

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