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H6378

Supelco

20α-Hydroxycholesterol

analytical standard

Sinônimo(s):

5-Cholestene-3β,20α-diol

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About This Item

Fórmula empírica (Notação de Hill):
C27H46O2
Número CAS:
516-72-3
Peso molecular:
402.65
Número MDL:
MFCD16661190
Código UNSPSC:
41116107
ID de substância PubChem:
329815230
NACRES:
NA.24

grau

analytical standard

Nível de qualidade

200

Ensaio

≥98%

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

clinical testing

Formato

neat

cadeia de caracteres SMILES

CC(C)CCC[C@](C)(O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1

chave InChI

MCKLJFJEQRYRQT-APGJSSKUSA-N

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Aplicação

20α-Hydroxycholesterol has been used as a standard to determine the concentration of 20α-hydroxycholesterol, present in food samples using gas chromatography with an ion trap detector coupled with mass spectrometer (GC-IT-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
SLCD0481
SLBZ8817
SLBX0926
SLBV4688
SLBV2080

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Woo-Kyun Kim et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 22(11), 1711-1719 (2007-07-20)
Specific oxysterols have been shown to be pro-osteogenic and anti-adipogenic. However, the molecular mechanism(s) by which oxysterols inhibit adipogenic differentiation is unknown. We show that the anti-adipogenic effects of osteogenic oxysterol, 20(S)-hydroxycholesterol, are mediated through a hedgehog-dependent mechanism(s) and are
M Arai et al.
Molecular and cellular endocrinology, 92(1), 91-97 (1993-03-01)
After postnatal day 1 (d1), the hypothalamo-pituitary-adrenal axis of neonatal rats becomes less responsive to certain stimuli for up to 2 weeks. The present study was designed to quantify the development of adrenocortical cell responsiveness to its normal secretagogue, adrenocorticotropic
H Guo et al.
Endocrinology, 127(3), 1234-1239 (1990-09-01)
Interstitial tissue of the testis consists of Leydig cells, macrophages, lymphocytes, plasma cells, mast cells and fibroblasts. Previously we have reported that interleukin-1 (IL-1) inhibits Leydig cell androgen production. In the present study, the effect of IL-2 was investigated. Leydig
M W Rooney et al.
Biochimica et biophysica acta, 820(1), 33-39 (1985-10-24)
Fourier transform infrared spectroscopy revealed that insertion of 20 alpha-hydroxycholesterol into human erythrocyte membranes (10% of total membrane sterol) immobilized the lipid acyl chains to a degree equivalent to enriching total membrane cholesterol by 50% (Rooney, M.W., Lange, Y. and
P B Hoyer et al.
Canadian journal of physiology and pharmacology, 63(3), 240-248 (1985-03-01)
Ovine luteal tissue contains two distinct steroidogenic cell types, small (8-20 microns) and large (greater than 20 microns), which differ based on morphological and biochemical criteria. Unstimulated small cells secrete low levels of progesterone, respond to LH or dibutyryl cAMP
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