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D0740000

Dextromethorphan hydrobromide

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

Dextromethorphan hydrobromide monohydrate, (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide

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About This Item

Fórmula empírica (Notação de Hill):
C18H25NO · HBr · H2O
Número CAS:
6700-34-1
Peso molecular:
370.32
Beilstein:
6453793
Número MDL:
MFCD02173901
Código UNSPSC:
41116107
ID de substância PubChem:
329798635
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

dextromethorphan

fabricante/nome comercial

EDQM

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

cadeia de caracteres SMILES

Br[H].[H]O[H].[H][C@]12CCCC[C@]13CCN(C)[C@H]2Cc4ccc(OC)cc34

InChI

1S/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/m1../s1

chave InChI

STTADZBLEUMJRG-IKNOHUQMSA-N

Informações sobre genes

human ... GRIN2A(2903) , SIGMAR1(10280)

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Dextromethorphan hydrobromide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Pictogramas

Skull and crossbonesEnvironment
GHS06,GHS09

Palavra indicadora

Danger

Frases de perigo

H301,H411

Classificações de perigo

Acute Tox. 3 Oral - Aquatic Chronic 2

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Phenacetin ≥98.0% (HPLC)

Sigma-Aldrich

77440

Phenacetin

Diclofenac sodium salt

Sigma-Aldrich

D6899

Diclofenac sodium salt

Melanie A Paquette et al.
The European journal of neuroscience, 36(9), 3224-3234 (2012-08-07)
Amantadine and dextromethorphan suppress levodopa (L-DOPA)-induced dyskinesia (LID) in patients with Parkinson's disease (PD) and abnormal involuntary movements (AIMs) in the unilateral 6-hydroxydopamine (6-OHDA) rat model. These effects have been attributed to N-methyl-d-aspartate (NMDA) antagonism. However, amantadine and dextromethorphan are
Tao-Cheng Wu et al.
PloS one, 7(9), e46067-e46067 (2012-10-11)
Vascular oxidative stress may be increased with age and aggravate endothelial dysfunction and vascular injury in hypertension. This study aimed to investigate the effects of dextromethorphan (DM), a NADPH oxidase inhibitor, either alone or in combination treatment, on blood pressure
Fixed drug eruption due to dextromethorphan with tolerance to other opioids.
G Davila-Fernández et al.
Journal of investigational allergology & clinical immunology, 23(4), 281-282 (2013-08-24)
K N Chi et al.
Cancer chemotherapy and pharmacology, 71(1), 237-244 (2012-10-16)
To assess the effect of abiraterone acetate plus prednisone on the pharmacokinetics of dextromethorphan HBr (CYP2D6 substrate) and theophylline (CYP1A2 substrate) in patients with metastatic castration-resistant prostate cancer (mCRPC). Men with progressive metastatic mCRPC who failed gonadotropin-releasing hormone therapy and
Muneaki Matsuo et al.
Pediatric neurology, 48(3), 200-205 (2013-02-20)
Acute encephalopathy with biphasic seizures and late reduced diffusion was recently established clinicoradiologically as an encephalopathy syndrome. The outcome of this encephalopathy is characterized by a low mortality rate and high incidence of neurologic sequelae. Although the exact pathogenesis of
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