BP720

Verapamil hydrochloride

British Pharmacopoeia (BP) Reference Standard

• Sinônimo(s): (±)-Verapamil hydrochloride, 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride
• Fórmula linear: (CH₃O)₂C₆H₃CH₂CH₂N(CH₃)(CH₂)₃C[C₆H₃(OCH₃)₂][CH(CH₃)₂]CN · HCl
• Número CAS: 152-11-4
• Peso molecular: 491.06
• Beilstein: 3647093
• Número MDL: MFCD00055208
• Código UNSPSC: 41116107
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• família API: verapamil
• forma: solid
• prazo de validade: limited shelf life, expiry date on the label
• fabricante/nome comercial: BP
• pf: 142 °C (dec.) (lit.)
• aplicação(ões): pharmaceutical; pharmaceutical small molecule
• formato: neat
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
• InChI: 1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
• chave InChI: DOQPXTMNIUCOSY-UHFFFAOYSA-N
• Informações sobre genes: human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

Descrição

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Verapamil hydrochloride BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Verapamil Prolonged-release Tablets

Verapamil Tablets

Verapamil Oral Solution

Verapamil Prolonged-release Capsules

Verapamil Injection

Ações bioquímicas/fisiológicas

α₁-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca²⁺ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.

Embalagem

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Outras notas

Sales restrictions may apply.

Informações de segurança

• Pictogramas: GHS06,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H301,H411
• Declarações de precaução: P264 - P273 - P301 + P310 - P391 - P405 - P501
• Classificações de perigo: Acute Tox. 3 Oral - Aquatic Chronic 2
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable