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01580590

Ginsenoside Rf

primary reference standard

Sinônimo(s):

(3β,6α,12β)-3,12,20-Trihydroxydammar-24-en-6-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside, Panaxoside Rf

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About This Item

Fórmula empírica (Notação de Hill):
C42H72O14
Número CAS:
52286-58-5
Peso molecular:
801.01
Número MDL:
MFCD00210509
Código UNSPSC:
85151701
ID de substância PubChem:
329747330
NACRES:
NA.24

grau

primary reference standard

prazo de validade

limited shelf life, expiry date on the label

fabricante/nome comercial

HWI

aplicação(ões)

food and beverages

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[H][C@]1(O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@@]2([H])O[C@H]3C[C@]4(C)[C@]([H])(C[C@@H](O)[C@]5([H])[C@]([H])(CC[C@@]45C)[C@@](C)(O)CC\C=C(/C)C)[C@@]6(C)CC[C@H](O)C(C)(C)[C@]36[H]

InChI

1S/C42H72O14/c1-20(2)10-9-13-42(8,52)21-11-15-40(6)28(21)22(45)16-26-39(5)14-12-27(46)38(3,4)35(39)23(17-41(26,40)7)53-37-34(32(50)30(48)25(19-44)55-37)56-36-33(51)31(49)29(47)24(18-43)54-36/h10,21-37,43-52H,9,11-19H2,1-8H3/t21-,22+,23-,24+,25+,26+,27-,28-,29+,30+,31-,32-,33+,34+,35-,36-,37+,39+,40+,41+,42-/m0/s1

chave InChI

UZIOUZHBUYLDHW-XUBRWZAZSA-N

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Descrição geral

Ginsenoside is a steroid-like molecular component having gonane steroid nucleus along with different sugar moieties attached to them found in the roots of Panax ginseng. Ginsenoside Rf, a variety of ginseng saponins with attached sugars moieties which inhibits the Ca2+ channels present in primary sensory neurons.
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Aplicação

It may be used as reference standard in HPLC-MS/MS analysis of human plasma to determine Ginsenosides from herbal products containing Panax ginseng and Panax quinquefolius.

Outras notas

This compound is commonly found in plants of the genus: panax

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
HWI02364
HWI01522-2
HWI01522-1

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J S Mogil et al.
Brain research, 792(2), 218-228 (1998-06-24)
Ginseng root, a traditional oriental medicine, contains more than a dozen biologically active saponins called ginsenosides, including one present in only trace amounts called ginsenoside-Rf (Rf). Previously, we showed that Rf inhibits Ca2+ channels in mammalian sensory neurons through a
De-qiang Dou et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 28(6), 522-524 (2004-03-16)
To isolate and elucidate the constituents from the roots of Commercial Ginseng. Column chromatography and HPLC were used to isolate chemical constituents. Physico-chemical characters and spectr-oscopic analysis were employed for structural identification. Sixteen compounds were identified as: notoginsenoside-R2(1), ginsenoside-Rg2(2), 20
Li Li et al.
Journal of pharmaceutical and biomedical analysis, 52(1), 66-72 (2010-01-19)
A new method using ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS) was developed for the rapid qualitative and quantitative analyses of Asian ginseng (Panax ginseng C.A.Meyer) in adulterated American ginseng (Panax quinquefolium L.) preparations within 2min. The method was
Kumar V S Nemmani et al.
Life sciences, 72(7), 759-768 (2002-12-14)
In the present study, the effect of ginsenoside Rf (Rf), a trace component of Panax ginseng on U-50,488H (U50), a selective kappa opioid-induced analgesia and its tolerance to analgesia was studied using the mice tail-flick test. In addition, the possible
Seok Choi et al.
Molecular pharmacology, 61(4), 928-935 (2002-03-20)
We have shown that ginsenoside Rf (Rf) regulates voltage-dependent Ca(2+) channels through pertussis toxin (PTX)-sensitive G proteins in rat sensory neurons. These results suggest that Rf can act through a novel G protein-linked receptor in the nervous system. In the
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Ginsenosides

Ginsenosides Separation in Ginseng. The HPLC method was first optimized using a ginsenoside standard mixture, and was then applied to a sample of American Ginseng root.

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