MABS1225
Anti-TXNIP Antibody, clone JY2
clone JY2, from mouse
Sinônimo(s):
Thioredoxin-interacting protein, Thioredoxin-binding protein 2, Vitamin D3 up-regulated protein 1
Faça loginpara ver os preços organizacionais e de contrato
About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
JY2, monoclonal
reatividade de espécies
human, mouse
técnica(s)
western blot: suitable
Isotipo
IgG1κ
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
ambient
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... TXNIP(10628)
Descrição geral
Thioredoxin-interacting protein (UniProt Q9H3M7; also known as Thioredoxin-binding protein 2, Vitamin D3 up-regulated protein 1) is encoded by the TXNIP (also known as VDUP1) gene (Gene ID 10628) in human. Thioredoxin interacting protein (TXNIP) is an alpha-arrestin protein that acts as an oxidative stress mediator that binds thioredoxin active cysteine residue and suppresses its antioxidant activity. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. TXNIP over-expression results in increased cellular ROS level and oxidative cell death, while TXNIP suppression enhances cellular resistance to oxidative injury. TXNIP is also shown to inhibit cellular glucose uptake by downregulating plasma membrane localization of glucose transporter 1 (GLUT1). TXNIP is required for the maturation of natural killer cells. Its expression is markedly down-regulated in tumor cells and its levels are correlated with clinical stage of cancer. Mice with mutations or knockout of TXNIP gene are much more susceptible to carcinogenesis than wild-type mice, indicating its role in cancer suppression. Ref.: Masutani, H., et al. (2012). J. Clin. Biochem. Nutr. 50, 23-34.
Especificidade
Clone JY2 detected TXNIP in adult mouse cardiomyocytes. No TXNIP target band was detected in cardiomyocytes from Txnip-null mice (Yoshioka, J., et al. (2007). Circ. Res. 101(12):1328-1338).
Imunogênio
Recombinant full-length human TXNIP protein.
Aplicação
Detect TXNIP/VDUP1 using this mouse monoclonal Anti-TXNIP Antibody, clone JY2, Cat. No. MABS1225, validated for use in Western Blotting.
Research Category
Signaling
Signaling
Western Blotting Analysis: A representative lot detected full-length human TXNIP, but not human TXNIP constructs lacking C-terminal end a.a. 302-391 sequence, exogenously expressed in HEK293 cells (Yoshioka, J., et al. (2007). Circ. Res. 101(12):1328-1338).
Western Blotting Analysis: A representative lot detected TXNIP in adult mouse cardiomyocytes. No TXNIP target band was detected in cardiomyocytes from Txnip-null mice (Yoshioka, J., et al. (2007). Circ. Res. 101(12):1328-1338).
Western Blotting Analysis: A representative lot detected TXNIP in adult mouse cardiomyocytes. No TXNIP target band was detected in cardiomyocytes from Txnip-null mice (Yoshioka, J., et al. (2007). Circ. Res. 101(12):1328-1338).
Qualidade
Evaluated by Western Blotting in HeLa cells.
Western Blotting Analysis: A 1:2,000 dilution of this antibody detected TXNIP in 10 µg of HeLa cell lysate.
Western Blotting Analysis: A 1:2,000 dilution of this antibody detected TXNIP in 10 µg of HeLa cell lysate.
Descrição-alvo
~53 kDa observed. 43.66/37.32 kDa (human isoform 1/2) and 44.36/44.29 kDa (mouse isoform 1/2) calculated. Uncharacterized bands may be observed in some lysate(s).
forma física
Format: Purified
Protein G purified.
Purified mouse IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Armazenamento e estabilidade
Stable for 1 year at 2-8°C from date of receipt.
Outras notas
Concentration: Please refer to lot specific datasheet.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Não está encontrando o produto certo?
Experimente o nosso Ferramenta de seleção de produtos.
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 1
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Mingyang Xin et al.
Cell & bioscience, 11(1), 208-208 (2021-12-16)
The majority of mammalian genome is composed of non-coding regions, where numerous long non-coding RNAs (lncRNAs) are transcribed. Although lncRNAs have been identified to regulate fundamental biological processes, most of their functions remain unknown, especially in metabolic homeostasis. Analysis of
Linhua Wang et al.
Journal of cellular physiology, 236(6), 4625-4639 (2021-01-17)
Sepsis-induced myocardial dysfunction (SIMD), a deadly symptom in sepsis patients, is mainly caused by cardiovascular inflammation. However, it remains unclear how systemic inflammation triggers and aggravates cardiovascular inflammation in the pathogenesis of SIMD. This study found that proinflammatory cytokines and
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica