MABF851

Anti-ERAP1 Antibody, clone 16A7.1

clone 16A7.1, from mouse

• Sinônimo(s): Endoplasmic reticulum aminopeptidase 1, A-LAP, Adipocyte-derived leucine aminopeptidase, Aminopeptidase PILS, ARTS-1, Endoplasmic reticulum aminopeptidase associated with antigen processing, PILS-AP, Puromycin-insensitive leucyl-specific aminopeptidase,
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: 16A7.1, monoclonal
• reatividade de espécies: human
• técnica(s): western blot: suitable
• Isotipo: IgG1κ
• nº de adesão NCBI: NP_001035548
• nº de adesão UniProt: Q9NZ08
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... ERAP1(51752)

Descrição

Descrição geral

Endoplasmic reticulum aminopeptidase 1 (UniProt Q9NZ08; also known as A-LAP, Adipocyte-derived leucine aminopeptidase, Aminopeptidase PILS, ARTS-1, Endoplasmic reticulum aminopeptidase associated with antigen processing, PILS-AP, Puromycin-insensitive leucyl-specific aminopeptidase, Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator) is encoded by the ERAP1 (also known as ALAP, APPILS, ARTS1, ERAAP, ERAAP1, KIAA0525, PILSAP) gene (ORF UNQ584/PRO1154; Gene ID 51752) in human. Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a single transmembrane protein belonging to the M1 family of zinc metallopeptidases. ERAP1 consists of an N-terminal transmembrane segment (a.a. 2-21) and a large lumenal domain (a.a. 22-941), with only the N-terminus methionine exposed cytoplasmically. ERAP1 processes peptides for major histocompatibility complex (MHC) class I presentation and promotes ectodomain shedding of several cytokine receptors, including TNF-R1, IL-6R alpha chain, and IL-1 type II decoy receptor (IL-1RII). Ankylosing spondylitis (AS) is a common, highly heritable form of inflammatory arthritis. Several ERAP1 single nucleotide polymorphic (SNP) variants are reported to influence the risk of AS in individuals carrying class I MHC allele HLA-B*27 and HLA-B*40:01.

Especificidade

Expected to react with both spliced isoforms of human ERAP1 (UniProt Q9NZ08-1 & Q9NZ08-2)

Imunogênio

Epitope: Internal.

GST-tagged recombinant human ERAP1 internal fragment.

Aplicação

Detect ERAP1 using this Anti-ERAP1 Antibody, clone 16A7.1 validated for use in Western Blotting.

Research Category
Inflammation & Immunology

Research Sub Category
Inflammation & Autoimmune Mechanisms

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected ERAP1 in 10 µg of K562 cell lysate.

Qualidade

Evaluated by Western Blotting in A431 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected ERAP1 in 10 µg of A431 cell lysate.

Descrição-alvo

~110 kDa observed. 107.2 kDa (isoform 1) and 107.8 kDa (Isoform 2) calculated.

forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Outras notas

Concentration: Please refer to lot specific datasheet.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable