Pular para o conteúdo
Merck
Todas as fotos(1)

Key Documents

MAB5280X

Sigma-Aldrich

Anti-Tyrosine Hydroxylase Antibody, clone 2/40/15, Alexa Fluor 488

clone 2/40/15, Chemicon®, from mouse

Sinônimo(s):

Anti-DYT14, Anti-DYT14|, Anti-DYT5b, Anti-TYH

Faça loginpara ver os preços organizacionais e de contrato


About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

conjugado

ALEXA FLUOR 488

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

2/40/15, monoclonal

reatividade de espécies

rat, bovine, quail, chicken

fabricante/nome comercial

Chemicon®

técnica(s)

immunohistochemistry: suitable

Isotipo

IgG2a

nº de adesão UniProt

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

rat ... Th(25085)

Especificidade

Tyrosine hydroxylase (TH) catalyzes the rate-determining initial step in the biosynthesis of catecholamines such as dopamine, noradrenaline and adrenaline. Therefore the antibody is used to stain dopaminergeous and adrenergeous neurons as well as the chromaffine tissue of the adrenal medulla. Cell lines such as the PC 12 line, which is derived from a rat pheochromocytoma also, show positive reactions. In immunoblots of adrenal medulla tissue, the antibody recognizes a single protein band in the molecular weight range of 56 - 60 kD.

Imunogênio

Purified tyrosine hydroxylase (EC 1.14.16.2) from a rat pheochromocytoma (2).

Aplicação

Anti-Tyrosine Hydroxylase Antibody, clone 2/40/15, Alexa Fluor 488 is an antibody against Tyrosine Hydroxylase for use in IH.
Immunohistochemistry

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Neuronal & Glial Markers

forma física

Purified immunoglobulin conjugated to Alexa Fluor 488. Liquid in Phosphate buffer with 15 mg/mL BSA as a stabilizer and 0.1% sodium azide.

Armazenamento e estabilidade

Maintain at 2-8°C in undiluted aliquots in the dark for up to 6 months after date of receipt.

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

ALEXA FLUOR is a trademark of Life Technologies
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Alexa Fluor is a registered trademark of Molecular Probes, Inc.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Não está encontrando o produto certo?  

Experimente o nosso Ferramenta de seleção de produtos.

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Selective and persistent activation of extracellular signal-regulated protein kinase by nitric oxide in glial cells induces neuronal degeneration in glutathione-depleted midbrain cultures.
Canals, Santiago, et al.
Molecular and Cellular Neurosciences, 24, 1012-1026 (2003)
Jonathan Wills et al.
PloS one, 6(3), e17953-e17953 (2011-03-30)
Tauopathic pathways lead to degenerative changes in Alzheimer's disease and there is evidence that they are also involved in the neurodegenerative pathology of Parkinson's disease [PD]. We have examined tauopathic changes in striatum of the α-synuclein (α-Syn) A53T mutant mouse.
Thomas Haggerty et al.
The European journal of neuroscience, 33(9), 1598-1610 (2011-04-02)
Although clinically distinct diseases, tauopathies and synucleinopathies share a common genesis and mechanisms, leading to overlapping degenerative changes within neurons. In human postmortem striatum of Parkinson's disease (PD) and PD with dementia, we have recently described elevated levels of tauopathy
Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness.
Kruger, Genevieve M, et al.
Neuron, 35, 657-669 (2002)

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica