MAB3507
Anti-Caspase 2 Antibody, clone 11B4
clone 11B4, Chemicon®, from rat
Sinônimo(s):
ICH-1
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
clone:
11B4, monoclonal
application:
ELISA
FACS
IP
WB
FACS
IP
WB
reatividade de espécies:
mouse, monkey, human, canine
técnica(s):
ELISA: suitable
flow cytometry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
flow cytometry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
citations:
12
Produtos recomendados
fonte biológica
rat
Nível de qualidade
forma do anticorpo
purified antibody
tipo de produto de anticorpo
primary antibodies
clone
11B4, monoclonal
reatividade de espécies
mouse, monkey, human, canine
fabricante/nome comercial
Chemicon®
técnica(s)
ELISA: suitable
flow cytometry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Isotipo
IgG2a
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... CASP2(835)
Especificidade
MAB3507 antibody recognizes a reactive epitope that lies in the P19 subunit of human Caspase-2 (ICH-1, Nedd-2).
Imunogênio
Raised against the P19 subunit of recombinant human Caspase-2 protein.
Aplicação
Anti-Caspase 2 Antibody, clone 11B4 is an antibody against Caspase 2 for use in ELISA, FC, IP & WB.
Research Category
Apoptosis & Cancer
Metabolism
Apoptosis & Cancer
Metabolism
Research Sub Category
Caspases
Enzymes & Biochemistry
Caspases
Enzymes & Biochemistry
Western blot: Recommended usage at 5 μg/ml, which has been found to detect endogenous Caspase-2 in 5 x 10E5 HeLa and MCF-7 cells.
Immunoprecipitation: Recommended concentration 1-5 μg/ml FACS: Recommended concentration 1 μg/ml. It is necessary to permeabilize the cell membrane prior to analysis.
EIA: Recommended concentration 0.5-1 μg/ml.
Immunohistochemistry: Use at 10-20 μg/ml. It is necessary to fix the cells in 4% Paraformaldehyde/0.18% Triton-X100 for 10 minutes prior to staining.
Optimal working dilutions must be determined by end user.
Immunoprecipitation: Recommended concentration 1-5 μg/ml FACS: Recommended concentration 1 μg/ml. It is necessary to permeabilize the cell membrane prior to analysis.
EIA: Recommended concentration 0.5-1 μg/ml.
Immunohistochemistry: Use at 10-20 μg/ml. It is necessary to fix the cells in 4% Paraformaldehyde/0.18% Triton-X100 for 10 minutes prior to staining.
Optimal working dilutions must be determined by end user.
Ligação
Replaces: 04-571
forma física
Format: Purified
Liquid with 0.05% Bronidox as a preservative.
Armazenamento e estabilidade
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment.
Orzaez, M; Guevara, T; Sancho, M; Perez-Paya, E
Cell Death & Disease null
Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury.
Ullman, E; Pan, JA; Zong, WX
Molecular and cellular biology null
Christopher J Del Nagro et al.
Cell cycle (Georgetown, Tex.), 13(2), 303-314 (2013-11-20)
Activation of Checkpoint kinase 1 (Chk1) following DNA damage mediates cell cycle arrest to prevent cells with damaged DNA from entering mitosis. Here we provide a high-resolution analysis of cells as they undergo S- and G₂-checkpoint bypass in response to
Brittany L Carroll et al.
FEBS open bio, 8(1), 27-40 (2018-01-13)
Sphingosine kinase 1 (SK1) is a lipid kinase whose activity produces sphingosine 1-phosphate, a prosurvival lipid associated with proliferation, angiogenesis, and invasion. SK1 overexpression has been observed in numerous cancers. Recent studies have demonstrated that SK1 proteolysis occurs downstream of
M Mancini et al.
The Journal of cell biology, 149(3), 603-612 (2000-05-03)
Caspases are an extended family of cysteine proteases that play critical roles in apoptosis. Animals deficient in caspases-2 or -3, which share very similar tetrapeptide cleavage specificities, exhibit very different phenotypes, suggesting that the unique features of individual caspases may
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