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MAB2511

Sigma-Aldrich

Anti-VCAM-1 Antibody, clone P8B1

clone P8B1, Chemicon®, from mouse

Sinônimo(s):

CD106

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

100

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

P8B1, monoclonal

reatividade de espécies

human

fabricante/nome comercial

Chemicon®

Isotipo

IgG2b

nº de adesão NCBI

NM_001078.2
NM_080682.1

nº de adesão UniProt

P19320

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... L1CAM(3897) , VCAM1(7412)

Especificidade

MAB2511 recognizes the human VCAM-1 molecule. The antibody inhibits VLA-4 (integrin alpha4beta1) binding and recognizes a different epitope than that which is recognized by MAB2144 (P3C4 clone).

Aplicação

Anti-VCAM-1 Antibody, clone P8B1 detects level of VCAM-1 & has been published & validated.
Function blocking

Optimal working dilutions must be determined by end user.

forma física

Format: Purified
Purified immunoglobulin. Liquid in 0.2 M phosphate buffer to 0.25 M NaCl, pH 7.6 with 0.1% sodium azide. Caution: Sodium azide is toxic. See online MSDS.

Armazenamento e estabilidade

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container′s cap.

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Max L B Grönloh et al.
EMBO reports, 24(1), e55483-e55483 (2022-11-17)
Upon inflammation, leukocytes leave the circulation by crossing the endothelial monolayer at specific transmigration "hotspot" regions. Although these regions support leukocyte transmigration, their functionality is not clear. We found that endothelial hotspots function to limit vascular leakage during transmigration events.
Thomas D Manes et al.
Arteriosclerosis, thrombosis, and vascular biology, 36(9), 1910-1918 (2016-07-23)
Circulating human T effector memory cell (TEM) recognition of nonself MHC (major histocompatibility complex) molecules on allograft endothelial cells can initiate graft rejection despite elimination of professional antigen-presenting cells necessary for naive T-cell activation. Our previous studies of CD4 TEM
Barbara Garmy-Susini et al.
The Journal of clinical investigation, 115(6), 1542-1551 (2005-05-20)
Neovascularization depends on vascular cell proliferation and on the stabilization of vessels by association of vascular smooth muscle-like pericytes with ECs. Here we show that integrin alpha4beta1 (VLA-4) and VCAM-1 promote close intercellular adhesion between ECs and pericytes and that

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