Pular para o conteúdo
Merck
Todas as fotos(2)

Documentos Principais

MAB1964

Sigma-Aldrich

Anti-Integrin β4 Antibody, clone 3E1

ascites fluid, clone 3E1, Chemicon®

Sinônimo(s):

CD104

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(2)

About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

forma do anticorpo

ascites fluid

tipo de produto de anticorpo

primary antibodies

clone

3E1, monoclonal

reatividade de espécies

human

fabricante/nome comercial

Chemicon®

técnica(s)

flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

Isotipo

IgG1

nº de adesão NCBI

NM_000213.3
NM_001005619.1
NM_001005731.1

nº de adesão UniProt

P16144

Condições de expedição

dry ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... ITGB4(3691)

Descrição geral

Integrin beta 4 is a glycoprotein which associates with the a6 integrin to form the a6/b4 complex. Integrin alpha 6/beta 4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Defects in Integrin beta 4 gene are a cause of epidermolysis bullosa letalis with pyloric atresia (EB PA); also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus. Moreover, defects in Integrin beta 4 gene are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). This nonlethal form of junctional epidermolysis bullosa is characterized by life long blistering of the skin, associated with hair and tooth abnormalities.

Especificidade

Reacts with Human beta4 integrin. The antigen is present on epithelial cells.

Aplicação

Stains human skin in immunofluorescence at approximately 1:200; acetone fixation required.

Also suitable for use in immunoprecipitation and flow cytometric assays.

Optimal working dilutions must be determined by the end user.
This Anti-Integrin β4 Antibody, clone 3E1 is validated for use in FC, IC, IH, IP for the detection of Integrin β4.

forma física

UnPurified ascites containing no preservatives.

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Não está encontrando o produto certo?  

Experimente o nosso Ferramenta de seleção de produtos.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Dominant-negative E-cadherin alters adhesion and reverses contact inhibition of growth in breast carcinoma cells
Vizirianakis, I. S. et al.
International journal of oncology, 21, 135-144 (2002)
Basement membrane diversity detected by monoclonal antibodies
Hessle, H. et al.
Differentiation, 26, 49-54 (1984)
Rachel M Levine et al.
Bioengineering & translational medicine, 1(2), 168-180 (2016-08-08)
The greatest obstacle to clinical application of cancer gene therapy is lack of effective delivery tools. Gene delivery vehicles must protect against degradation, avoid immunogenic effects and prevent off target delivery which can cause harmful side effects. PEGylated liposomes have
Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity.
A Chen, I Cuevas, PA Kenny, H Miyake, K Mace, C Ghajar, A Boudreau, M Bissell, N Boudreau
Cancer Research null
Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties.
Gudjonsson, T; Villadsen, R; Nielsen, HL; R?nnov-Jessen, L; Bissell, MJ; Petersen, OW
Genes & Development null
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica