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M04S-03-5PK

Millipore

CellASIC ONIX switching plate mammalian cells (4 chamber)

The M04 switching plates enable continuous perfusion culture for live cell analysis. Laminar flow provides rapid & uniform solution exchange for maximum cell health. The glass coverslide bottom surface ensures the highest resolution optical viewing.

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About This Item

Código UNSPSC:
41104923
eCl@ss:
32011202
NACRES:
NB.22

Materiais

PMMA
glass
polycarbonate
polydimethylsiloxane (PDMS)

fabricante/nome comercial

CellASIC® ONIX

L × C × A

85.48 mm × 127.76 mm × 14.35 mm

compatibilidade

for use with cells sized up to 50.0 μm

Condições de expedição

ambient

Categorias relacionadas

Descrição geral

CellASIC® ONIX switching plate mammalian cells (4 chambers) enable continuous perfusion culture for live cell analysis. Laminar flow provides a rapid and uniform solution exchange for maximum cell health. The glass cover slide bottom surface ensures the highest resolution of optical viewing.

Aplicação

CellASIC® ONIX switching plate mammalian cells(4 chambers) have been used:
  • in live-cell imaging to study the contribution of phi-particle in the autoinhibition of dynein and the activation of dynein by dynactin
  • in live-cell imaging of fcSAgA binding and immunoglobulin M surface clustering by fluorescence microscopy
  • in multiple epidermal growth factor (EGF)pulse experiments
The CellASIC® ONIX switching plate is suitable for use in:
  • time-lapse analysis of adherent cells
  • long-term continuous perfusion experiments (3 days typical)
  • solution exchange experiments (induction, inhibition, drug dosing, etc.)
  • automated immunostaining and on-demand fixation of live cells within the culture chamber
  • comparison of up to four different cell types or exposure conditions (media components) in parallel, temperature, and gas atmospheric control (temperature shift, anoxic conditions, etc.)

Características e benefícios

  • Compatible with CellASIC® ONIX2 Microfluidic system and ONIX2 Manifolds
  • Enables perfusion-based, long-term, live-cell analysis with solution switching
  • The plate offers a controlled and dynamic microenvironment for 2D and 3D cell cultures

Informações legais

CELLASIC is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Brittany L Hartwell et al.
Biomacromolecules, 18(6), 1893-1907 (2017-05-06)
A pressing need exists for antigen-specific immunotherapies (ASIT) that induce selective tolerance in autoimmune disease while avoiding deleterious global immunosuppression. Multivalent soluble antigen arrays (SAgAPLP:LABL), consisting of a hyaluronic acid (HA) linear polymer backbone cografted with multiple copies of autoantigen
Kai Zhang et al.
Cell, 169(7), 1303-1314 (2017-06-13)
Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capable of long-distance processive movement along microtubules. However, it is unclear why dynein-1 moves poorly on its own or how it is activated by dynactin. Here, we
Angel Stanoev et al.
Cell systems, 7(3), 295-309 (2018-08-27)
The proto-oncogenic epidermal growth factor receptor (EGFR) is a tyrosine kinase whose sensitivity to growth factors and signal duration determines cellular behavior. We resolve how EGFR's response to epidermal growth factor (EGF) originates from dynamically established recursive interactions with spatially

Artigos

Real-time imaging of adherent and non-adherent cell interactions: utility of an automated microfluidic trap platform to recapitulate in vivo cell culture microenvironment

This page describes novel microfluidic approaches to trap two different cell types in precise locations in order to image and study their interactions over time.

Primary Neuron Culture and Analysis Facilitated by the CellASIC® ONIX Microfluidic Platform

This page describes a novel, optimized microfluidic platform for long-term culture of primary neurons to monitor dynamic cellular processes in real time.

Dynamic Live Cell Imaging of Caspase Mediated Apoptosis and Cellular Hypoxia in Lymphocytes and Cancer Cells Using the CellASIC® ONIX2 Microfluidic Platform

Application note on how the CellASIC® ONIX2 microfluidic system can be used to analyze caspase-3 mediated apoptosis/cell death and cellular hypoxia in live immune and cancer cell lines.

Demonstration of Long-Term Culture and In-Plate Staining Protocols Using the Cellasic® ONIX Microfluidic Platform

This page shows the long-term culture and in-plate staining protocols using the CellASIC ONIX Microfluidic platform.

Conteúdo relacionado

CellASIC® ONIX live cell analysis platform for neural stem cell microenvironment control

This article describes CellASIC® ONIX live cell analysis platform for neural stem cell microenvironment control

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