HMMP1MAG-55K
MILLIPLEX® Human MMP Magnetic Bead Panel 1 - Immunology Multiplex Assay
Matrix Metalloproteinase Bead-Based Multiplex Assays using the Luminex technology enable the simultaneous analysis of multiple MMPs biomarkers in human serum, plasma and cell culture samples.
Sinônimo(s):
Human matrix metalloproteinase multiplex kit, Luminex® Human MMP immunoassay, Millipore human MMP panel
Faça loginpara ver os preços organizacionais e de contrato
About This Item
Código UNSPSC:
12161503
eCl@ss:
32161000
NACRES:
NA.84
Produtos recomendados
Nível de qualidade
reatividade de espécies
human
fabricante/nome comercial
Milliplex®
assay range
standard curve range: 146-150,000 pg/mL
(MMP-3)
standard curve range: 58-60,000 pg/mL
(MMP-13)
standard curve range: 98-100,000 pg/mL
(MMP-12)
técnica(s)
multiplexing: suitable
método de detecção
fluorometric (Luminex xMAP)
Condições de expedição
wet ice
Descrição geral
MMPs (matrix metalloproteinases), a family of zinc proteases responsible for the breakdown of extracellular matrix (ECM), play a key role in normal physiological processes, such as embryonic development and tissue morphogenesis, tissue and bone remodeling, wound healing, and angiogenesis. These processes rely on MMPs′ role in the cleavage of cell surface receptors, the release of apoptotic ligands, cell proliferation and differentiation, and chemokine activity modulation. Similar in structure, MMPs are synthesized and secreted as inactive pro-enzymes that require proteolytic cleavage for activation. This process can be mediated by serine proteases or other MMPs. An increase in MMP expression occurs in response to a wide range of stimuli, including adhesion molecules, growth factors, cytokines, and hormones. Regulation of MMP activity is controlled primarily by TIMPs (tissue inhibitors of metalloproteinases). Therefore, disruption of the MMP/TIMP balance can result in arthritis, cardiovascular disease and tumor growth and metastasis.
MILLIPLEX® Human MMP Bead Panel 1 is a 3 plex kit to be used for the simultaneous quantification of any or all the following analytes in serum/plasma samples: MMP-3, MMP-12, and MMP-13.
The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.
Panel Type: Cytokines/Chemokines
MILLIPLEX® Human MMP Bead Panel 1 is a 3 plex kit to be used for the simultaneous quantification of any or all the following analytes in serum/plasma samples: MMP-3, MMP-12, and MMP-13.
The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.
Panel Type: Cytokines/Chemokines
Especificidade
Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
Aplicação
- Analytes: MMP-3, MMP-12, MMP-13
- Recommended Sample type: Serum and plasma; this panel has also been analytically verified in urine, tissue/cell lystate and culture supernatant samples
- Recommended Sample dilution: Neat
- Assay Run Time: One day
- Research Category: Inflammation & Immunology
Características e benefícios
Design your multiplex kit by choosing available analytes within this panel.
Armazenamento e estabilidade
Recommended storage for kit components is 2 - 8°C.
Outras notas
Sensitivity: See protocol for sensitivities of individual analytes
Informações legais
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
Órgãos-alvo
Respiratory Tract
Código de classe de armazenamento
10 - Combustible liquids
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Dynamics of cerebrospinal fluid levels of matrix metalloproteinases in human traumatic brain injury.
Karolina Minta et al.
Scientific reports, 10(1), 18075-18075 (2020-10-24)
Matrix metalloproteinases (MMPs) are extracellular enzymes involved in the degradation of extracellular matrix (ECM) proteins. Increased expression of MMPs have been described in traumatic brain injury (TBI) and may contribute to additional tissue injury and blood-brain barrier damage. The objectives
Jonathan H Soslow et al.
Journal of cardiac failure, 25(4), 259-267 (2019-02-15)
Cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD). Standard cardiac biomarkers are poor indicators of DMD cardiovascular disease. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) regulate collagen turnover. Given the cardiac fibrosis seen in
Charbel Moussa et al.
Journal of neuroinflammation, 14(1), 1-1 (2017-01-15)
Treatment of mild-moderate Alzheimer's disease (AD) subjects (N = 119) for 52 weeks with the SIRT1 activator resveratrol (up to 1 g by mouth twice daily) attenuates progressive declines in CSF Aβ40 levels and activities of daily living (ADL) scores. For this retrospective study
Jin-Yih Low et al.
Molecular cancer research : MCR, 18(9), 1414-1426 (2020-06-05)
Lipid uptake occurs through caveolae, plasma membrane invaginations formed by caveolins (CAV) and caveolae-associated protein 1 (CAVIN1). Genetic alterations of CAV1N1 and CAV1 modify lipid metabolism and underpin lipodystrophy syndromes. Lipids contribute to tumorigenesis by providing fuel to cancer metabolism
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica