ABN25

Anti-Thyroid Hormone Receptor β-1 Antibody

from rabbit, purified by affinity chromatography

• Sinônimo(s): Thyroid hormone receptor beta, Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• purificado por: affinity chromatography
• reatividade de espécies: mouse, human
• reatividade da espécie (prevista por homologia): rat (based on 100% sequence homology)
• técnica(s): western blot: suitable
• nº de adesão NCBI: NP_000452
• nº de adesão UniProt: P10828
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... THRB(7068)

Descrição

Descrição geral

Thyroid hormone receptor β-1 operates as a hormone-dependent transcriptional regulator that binds DNA sequences and is activated by 3,5,3’-l-triiodothyronine (T3). Thyroid hormone receptor β-1 is important in vertebrate development, specifically in developing limbs and face. 9-cis-retinoic acid receptor (RXR) and retinoic acid receptor (RAR) receptor families are often associated with thyroid hormone receptor β-1 and form homodimers and heterodimers. Mutations in thyroid hormone receptor β-1 have been associated with general resistance to thyroid hormones which tend to cause significant behavioral abnormalities. Recent research has linked thyroid hormone receptor β-1 to tumor suppression, where the receptor has commonly been found to be disrupted in the occurrence of cancer.

Imunogênio

KLH-conjugated linear peptide corresponding to human Thyroid Hormone receptor β-1.

Aplicação

Anti-Thyroid Hormone Receptor β-1 Antibody is a rabbit polyclonal antibody for detection of Thyroid Hormone Receptor β-1 also known as Thyroid hormone receptor beta, c-erbA-2, c-erbA-beta & has been validated in WB.

Research Category
Neuroscience

Research Sub Category
Hormones & Receptors

Qualidade

Evaluated by Western Blot in HeLa nuclear extract.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Thyroid Hormone receptor β-1 on 10 µg of HeLa nuclear extract.

Descrição-alvo

~60 kDa observed. An uncharacterized band may be observed at ~45 kDa in some lysates.

forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Nota de análise

Control
HeLa nuclear extract

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable