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Documentos Principais

AB5702

Sigma-Aldrich

Anti-HES-1 Antibody

Chemicon®, from rabbit

Sinônimo(s):

Hairy 1

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

purificado por

affinity chromatography

reatividade de espécies

rodent, human, mouse

fabricante/nome comercial

Chemicon®

técnica(s)

immunohistochemistry: suitable
western blot: suitable

nº de adesão NCBI

NM_005524.2

nº de adesão UniProt

Q14469

Condições de expedição

dry ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... HES1(3280)
mouse ... Hes1(15205)

Descrição geral

Hes1 is a transcriptional repressor of genes that require a bHLH protein for their transcription. It may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Hes1 is expressed in developing neuroectodermal and endodermal endocrine tissues, and Hes1 deficient embryos show severe defects in neuronal development, as well as pancreatic hypoplasia.

Especificidade

Reactivity with other species has not been confirmed.
Recognizes HES-1 (Hairy family), a Helix-loop-helix class of transcription factor.

Imunogênio

Synthetic peptide.

Aplicação

Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

Neuronal & Glial Markers
This Anti-HES-1 Antibody is validated for use in IH, WB for the detection of HES-1.
Western Blot:
1:200-1:1,000 dilution using ECL.

Immunohistochemistry:
1:200-1:1,000 dilution of a previous lot worked.

Optimal working dilutions must be determined by the end user.

Descrição-alvo

29 kDa

forma física

ImmunoAffinity Purified
Purified rabbit polyclonal in buffer containing a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.

Armazenamento e estabilidade

Stable for 1 year at -80ºC from date of receipt.

Nota de análise

Control
Human neural stem cells, Raji cell lysate.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Combined in silico and in vivo analyses reveal role of Hes1 in taste cell differentiation.
Ota, MS; Kaneko, Y; Kondo, K; Ogishima, S; Tanaka, H; Eto, K; Kondo, T
PLoS Genetics null
An aquaporin 3-notch1 axis in keratinocyte differentiation and inflammation.
Guo, L; Chen, H; Li, Y; Zhou, Q; Sui, Y
Testing null
Notch signaling and Atoh1 expression during hair cell regeneration in the mouse utricle.
Wang GP, Chatterjee I, Batts SA, Wong HT, Gong TW, Gong SS, Raphael Y
Hearing Research null
Notch signaling in descending thoracic aortic aneurysm and dissection.
Zou, S; Ren, P; Nguyen, M; Coselli, JS; Shen, YH; LeMaire, SA
Testing null
Wen-Cheng Chung et al.
Oncoscience, 4(9-10), 131-138 (2017-11-17)
Kras mutations and increased Notch activation occur frequently in gallbladder cancer. However, their roles in gallbladder carcinogenesis have not been defined. This study was aimed at determining whether expression of mutant Kras was sufficient to induce gallbladder carcinoma and whether
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