AB5128
Anti-Melanocortin Receptor-2 Antibody
Chemicon®, from rabbit
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
purificado por
affinity chromatography
reatividade de espécies
mouse, rat, human
fabricante/nome comercial
Chemicon®
técnica(s)
ELISA: suitable
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
dry ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... MC2R(4158)
Descrição geral
Mouse Melanocortin receptor 2 (MC2-R or ACTH-R) is a 297 aa transmembrane protein belonging to the family of G-Protein coupled receptors. It is a receptor for ACTH. It is found in melanocyte and corticoadrenal tissues. Defects in insensitivity or resistance to ACTH and characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.
Imunogênio
A 17 aa peptide (designated MCR21) from the 4th cytoplasmic domain of mouse MC2-R.
Aplicação
Research Category
Neuroscience
Neuroscience
Research Sub Category
CNS Control of Metabolism
Hormones & Receptors
CNS Control of Metabolism
Hormones & Receptors
This Anti-Melanocortin Receptor-2 Antibody is validated for use in ELISA, WB for the detection of Melanocortin Receptor-2.
Western blot: 1-10 μg/mL using Chemiluminescence technique
ELISA: 1:10,000 - 100,000
Optimal working dilutions must be determined by end user.
ELISA: 1:10,000 - 100,000
Optimal working dilutions must be determined by end user.
forma física
Affinity Purified 1mg/mL solution in PBS, with 0.1% BSA.
Armazenamento e estabilidade
Can be refrigerated at 2-8°C in undiluted aliquots for short term use. Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
M Kubo et al.
Gene, 153(2), 279-280 (1995-02-14)
A genomic DNA encoding a mouse adrenocorticotropin (ACTH) receptor was isolated. The predicted 296-amino-acid sequence showed 88.9 and 78.7% identities to the human and bovine homologues, respectively.
C Tsigos et al.
The Journal of clinical investigation, 92(5), 2458-2461 (1993-11-01)
Isolated glucocorticoid deficiency (IGD) is an autosomal recessive disorder characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. The cDNA and gene of the human ACTH receptor were recently cloned. The gene encodes a 297-amino acid protein that belongs to
M Raikhinstein et al.
Biochimica et biophysica acta, 1220(3), 329-332 (1994-02-17)
We isolated five independent cDNAs of nearly 3000 bp for the bovine ACTH receptor by screening adrenal cortex cDNA libraries with a PCR cloned cDNA fragment. The deduced receptor sequence includes 297 residues (M(r) = 33,258) with 81% identity with
A J Clark et al.
Lancet (London, England), 341(8843), 461-462 (1993-02-20)
Familial glucocorticoid deficiency is an uncommon disorder that appears to be due to congenital insensitivity or resistance to adrenocorticotropin (ACTH), and is usually inherited in an autosomal recessive pattern. We investigated the DNA base sequence in a family with this
Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training.
Campbell, JE; Rakhshani, N; Fediuc, S; Bruni, S; Riddell, MC
Journal of Applied Physiology (1985)
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