553031

RAGE Antagonist Peptide, RAP

The RAGE Antagonist Peptide, RAP controls the biological activity of RAGE.

• Sinônimo(s): RAGE Antagonist Peptide, RAP, ELKVLMEKEL
• Fórmula empírica (Notação de Hill): C₅₇H₁₀₁N₁₃O₁₇S
• Peso molecular: 1272.55
• Código UNSPSC: 12352111
• NACRES: NA.77

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥95% (HPLC)
• forma: powder
• potência: 2 μM IC₅₀
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white
• solubilidade: water: 5 mg/mL
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.

Ações bioquímicas/fisiológicas

Primary Target
RAGE

Reversible: yes

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Sequência

Ac-ELKVLMEKEL-NH2

forma física

Supplied as a trifluoroacetate salt.

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Arumugam, T., et al. 2012. Clin Cancer Res.18, 4356.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable